4-(3,5-dimethylpyrazol-1-yl)-N,N-diethyl-6-piperidin-1-yl-1,3,5-triazin-2-amine | 1160616-95-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 4-(3,5-dimethylpyrazol-1-yl)-N,N-diethyl-6-piperidin-1-yl-1,3,5-triazin-2-amine
• CAS: 1160616-95-4
• 化学式: C₁₇H₂₇N₇
• 分子量: 329.448
• InChiKey: MGKYUICFCAHYIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  63
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N,N-diethyl-4-hydrazinyl-6-piperidin-1-yl-1,3,5-triazin-2-amine 、 乙酰丙酮 在 三甲胺 作用下， 以 甲苯 为溶剂， 以60%的产率得到4-(3,5-dimethylpyrazol-1-yl)-N,N-diethyl-6-piperidin-1-yl-1,3,5-triazin-2-amine
  参考文献：
  名称：

  Synthesis and structure of new 1,3,5-triazine-pyrazole derivatives

  摘要：

  We have studied the reaction of methylenedicarbonyl compounds with 4,6-disubstituted 2-hydrazinyl-1,3,5-triazine in order to obtain novel coupled biheterocyclic aromatic systems with potential bioactivity. Reaction conditions were studied and optimized, and a series of 4,6-disubstituted 2-(1H-pyrazolyl)-1,3,5-triazines were obtained with good yield. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.054

文献信息

• Synthesis and structure of new 1,3,5-triazine-pyrazole derivatives
  作者：Svetlana N. Mikhaylichenko、Saurabh M. Patel、Shadi Dalili、Aleksey A. Chesnyuk、Vladimir N. Zaplishny

  DOI：10.1016/j.tetlet.2009.03.054

  日期：2009.5

  We have studied the reaction of methylenedicarbonyl compounds with 4,6-disubstituted 2-hydrazinyl-1,3,5-triazine in order to obtain novel coupled biheterocyclic aromatic systems with potential bioactivity. Reaction conditions were studied and optimized, and a series of 4,6-disubstituted 2-(1H-pyrazolyl)-1,3,5-triazines were obtained with good yield. (C) 2009 Elsevier Ltd. All rights reserved.