Dipotassium 5'-inosinate | 20262-26-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: Dipotassium 5'-inosinate
• 英文别名: dipotassium;[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl phosphate
• CAS: 20262-26-4
• 化学式: C10H11K2N4O8P
• 分子量: 424.39
• InChiKey: DLDSRSUKRMPQKB-IDIVVRGQSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -9.0
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  186
• 氢给体数：
  3
• 氢受体数：
  11

制备方法与用途

鉴别试验

• 易溶于水，几乎不溶于乙醇（OT-42）。
• 紫外吸光度：同“02007，5’-肌苷酸二钠”。
• 钾试验：阳性（IT-27）。
• 核糖试验：阳性。同“02006，5'-鸟苷酸二钠”。
• 有机磷试验：阳性。同“02035，5’-鸟苷酸二钾”。

含量分析

方法同“02007，5’-肌苷酸二钠”，惟含量按下式计算： [ \text{含量(%)} = \frac{A}{286.5} \times \frac{250000}{\text{试样量(mg)}} \times \frac{100}{（100-\text{水分(%))}} \times 100 ]

毒性

ADI不作特殊规定（FAO/WHO，2001）。

使用限量

GMP为限。

化学性质

无色或白色结晶，或白色结晶性粉末，无臭，有特殊滋味。

用途

调味剂。

生产方法

由肌苷酸作选择性羟基磷酸化后，再用氢氧化钾中和、结晶而得。

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• [EN] IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS<br/>[FR] PERFECTIONNEMENTS APPORTÉS OU ASSOCIÉS À DES COMPOSÉS ORGANIQUES
  申请人：GIVAUDAN SA

  公开号：WO2021063942A1

  公开（公告）日：2021-04-08

  The use of compounds according to formula (I) and with X, Y = –NH– or –O–, wherein at least X or Y is –NH–, in the form of any one of its stereoisomers or a mixture thereof, wherein is indicating a carbon-carbon single or double bond, and wherein one carbon-carbon double bond is present either at C2 or C3, the wavy bond is indicating an unspecified configuration of the adjacent double bond, as umami tastant.

  根据公式（I）中的化合物的使用，其中X、Y = -NH-或-O-，其中至少X或Y是-NH-，以其立体异构体或其混合物的形式，其中指示碳-碳单键或双键，并且其中一个碳-碳双键存在于C2或C3上，波浪键表示相邻双键的未指定构型，作为鲜味味觉物质。
• Organic Compounds
  申请人：Hofmann Thomas Frank

  公开号：US20120231140A1

  公开（公告）日：2012-09-13

  Provided are umami taste and savoury flavour enhancing compounds of formula (I) wherein R 1 is selected from 0 and OH, the dotted line representing a bond present when R 1 is 0, R 2 is a hydrocarbon residue having 6 to 22 carbon atoms, comprising from 0-4 unsaturated carbon-carbon bonds. The compounds can be added to food products, beverages and other consumable products.

  提供了公式（I）的鲜味和美味增强化合物，其中R1从0和OH中选择，当R1为0时，点线表示存在键，R2是具有6到22个碳原子的烃基残基，包括0-4个不饱和碳-碳键。这些化合物可以添加到食品产品，饮料和其他可消费产品中。
• Salt substitute composition
  申请人：NABISCO BRANDS, Inc.

  公开号：EP0124254A1

  公开（公告）日：1984-11-07

  A salt substitute composition comprising: a) from about 70% to about 98% by weight potassium chloride, b) from about 1 % to about 20% by weight of a non-reducing sugar, preferably sucrose, c) from about 0.3 % to about 15% by weight of an edible organic acid, preferably adipic acid, d) from about 0.5 % to about 10% by weight of a glutamate salt, preferably potassium glutamate, and from about 0.15% to about 5% by weight of an anti- caking agent, preferably tricalcium phosphate, said percentages adding up to 100%, is stable and palatable even after storage at high temperatures over an extended period of time. Use of a non-reducing sugar achieves the beneficial effects of masking the undesirable bitter taste of the potassium ion without reacting with the glutamate salt as do reducing sugars.

  一种盐替代物组合物，包括：a) 按重量计，从约 70% 到约 98% 的氯化钾；b) 按重量计，从约 1% 到约 20% 的非还原糖，最好是蔗糖；c) 按重量计，从约 0.3% 到约 15% 的食用有机酸，最好是己二酸；d) 按重量计，从约 0.c) 约 0.3 % 至约 15%（按重量计）的食用有机酸，最好是己二酸；d) 约 0.5 % 至约 10%（按重量计）的谷氨酸盐，最好是谷氨酸钾；以及约 0.15 % 至约 5%（按重量计）的防结块剂，最好是磷酸三钙。使用非还原糖可以掩盖钾离子的苦味，而不会像还原糖那样与谷氨酸盐发生反应。

表征谱图