| 592530-80-8

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• CAS: 592530-80-8
• 化学式: C₁₆H₂₆Li₂
• 分子量: 232.264
• InChiKey: FPCZDTKFQVZJLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.64
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-氰基吡啶 、 在 六甲基磷酰三胺 作用下， 以 乙醚 、 正戊烷 为溶剂， 反应 1.5h， 以222 mg的产率得到3-(2-pyridyl)-1,4-dibutyl-5,6,7,8-tetrahydroisoquinoline
  参考文献：
  名称：

  Novel Cycloaddition of Nitriles with Monolithio- and Dilithiobutadienes

  摘要：

  Two novel and synthetically useful reaction patterns of organolithium compounds with nitriles are reported to afford pyridine derivatives as the final products. Both 1-lithio-1,3-dienes and 1,4-dilithio-1,3-dienes, which can be easily generated in situ by lithiation of their corresponding iodo compounds, react with nitriles in the presence of HMPA to form substituted pyridines including 2,2'-bipyridines and tetrahydroisoquinolines in high yields.

  DOI：

  10.1021/ja0262176
• 作为产物：
  描述：

  (1Z,2Z)-1,2-bis(1-iodopentylidene)cyclohexane 在 叔丁基锂 作用下， 以 正戊烷 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Novel Cycloaddition of Nitriles with Monolithio- and Dilithiobutadienes

  摘要：

  Two novel and synthetically useful reaction patterns of organolithium compounds with nitriles are reported to afford pyridine derivatives as the final products. Both 1-lithio-1,3-dienes and 1,4-dilithio-1,3-dienes, which can be easily generated in situ by lithiation of their corresponding iodo compounds, react with nitriles in the presence of HMPA to form substituted pyridines including 2,2'-bipyridines and tetrahydroisoquinolines in high yields.

  DOI：

  10.1021/ja0262176

文献信息

• Novel Cycloaddition of Nitriles with Monolithio- and Dilithiobutadienes
  作者：Jinglong Chen、Qiuling Song、Congyang Wang、Zhenfeng Xi

  DOI：10.1021/ja0262176

  日期：2002.6.1

  Two novel and synthetically useful reaction patterns of organolithium compounds with nitriles are reported to afford pyridine derivatives as the final products. Both 1-lithio-1,3-dienes and 1,4-dilithio-1,3-dienes, which can be easily generated in situ by lithiation of their corresponding iodo compounds, react with nitriles in the presence of HMPA to form substituted pyridines including 2,2'-bipyridines and tetrahydroisoquinolines in high yields.