1-[4-(6-Chloropyridazin-3-yl)piperazin-1-yl]-2-(4-cyclopropyl-3-fluorophenyl)ethan-1-one | 2361124-03-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-[4-(6-Chloropyridazin-3-yl)piperazin-1-yl]-2-(4-cyclopropyl-3-fluorophenyl)ethan-1-one
• 英文别名: 1-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]-2-(4-cyclopropyl-3-fluorophenyl)ethanone
• CAS: 2361124-03-8
• 化学式: C₁₉H₂₀ClFN₄O
• 分子量: 374.8
• InChiKey: GGZFNPBICDFCKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  49.3
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES
  申请人：St. Jude Children's Research Hospital, Inc.

  公开号：EP3731844A1

  公开（公告）日：2020-11-04
• METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR
  申请人：ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

  公开号：US20210023081A1

  公开（公告）日：2021-01-28

  The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• [EN] METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR<br/>[FR] MÉTHODES DE TRAITEMENT DE TROUBLES ASSOCIÉS À CASTOR
  申请人：[en]ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

  公开号：WO2022133034A1

  公开（公告）日：2022-06-23

  The present disclosure relates to methods of identifying subjects in need of treatment for, e.g., a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. The methods may comprise assessing levels of carnitines, CoA, and/or various metabolites and biomarkers and administration of therapeutics useful in the treatment of CASTOR disorders, metabolic diseases, and/or neurological diseases. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present inventions.