(3-Nitrophenyl)-dioxido-oxo-lambda5-phosphane | 111192-87-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-Nitrophenyl)-dioxido-oxo-lambda5-phosphane
• 英文别名: (3-nitrophenyl)-dioxido-oxo-λ5-phosphane
• CAS: 111192-87-1
• 化学式: C₆H₄NO₅P
• 分子量: 201.075
• InChiKey: OXWXINKWKITCIH-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• GLUTAMATE DERIVATIVES OR SALTS THEREOF
  申请人：AJINOMOTO CO., INC.

  公开号：US20130017603A1

  公开（公告）日：2013-01-17

  Compounds having an excellent CaSR agonist activity are in demand. The invention provides glutamate derivatives or salts thereof, pharmaceutical compositions comprising the glutamate derivatives, preventive or therapeutic agents for diarrhea, hyperparathyroidism or peptic ulcer.

  有出色的CaSR激动剂活性的化合物需求。本发明提供了谷氨酸衍生物或其盐，包括谷氨酸衍生物的药物组合物，用于预防或治疗腹泻，甲状旁腺功能亢进或消化性溃疡的药物。
• CASR AGONISTS
  申请人：AJINOMOTO CO., INC.

  公开号：US20140303122A1

  公开（公告）日：2014-10-09

  By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.

  通过搜索具有CaSR激动活性的各种化合物，本发明提供了包括该化合物的CaSR激动剂、药物组合物、预防或治疗腹泻的药物和增强鲜味的药物。更具体地，本发明提供了包括具有CaSR激动活性的谷氨酸衍生物或其药学上可接受的盐的CaSR激动剂、药物组合物、预防或治疗腹泻的药物和增强鲜味的药物。
• PROPHYLACTIC AGENT OR THERAPEUTIC AGENT FOR DIABETES OR OBESITY
  申请人：AJINOMOTO CO., INC

  公开号：US20130102570A1

  公开（公告）日：2013-04-25

  A medicament having an excellent CaSR agonist action which enables the prevention or treatment of diabetes or obesity is provided by a composition comprising the compound represented by general formula (I) as defined, or a salt thereof.

  提供一种药物，其具有优异的CaSR激动剂作用，可预防或治疗糖尿病或肥胖症，该药物组成物包括由一般式（I）所表示的化合物或其盐。
• AMINO PYRIMIDINE ANTICANCER COMPOUNDS
  申请人：OSI PHARMACEUTICALS, LLC

  公开号：US20130231306A1

  公开（公告）日：2013-09-05

  Compounds of Formula 1, as shown below and defined herein: and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.

  化学式为1的化合物，如下所示并在此定义：以及药学上可接受的盐，合成方法，中间体，制剂和治疗疾病的方法，包括至少部分由FAK介导的癌症。
• US8877739B2
  申请人：——

  公开号：US8877739B2

  公开（公告）日：2014-11-04