[[(2R,3R,4S,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: [[(2R,3R,4S,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate
• 化学式: C₂₁H₃₆N₇O₁₆P₃S
• 分子量: 767.5
• InChiKey: RGJOEKWQDUBAIZ-FXQJDNFMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.8
• 重原子数：
  48
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  348
• 氢给体数：
  10
• 氢受体数：
  21

文献信息

• Teicoplanin analogs and uses thereof
  申请人：Academia Sinica

  公开号：US10316064B2

  公开（公告）日：2019-06-11

  Described herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting bacterial growth. Methods of using the compounds for treating and/or preventing bacterial infection as well as methods of preparing the compounds are also described

  本文描述的是式 (I) 化合物或其药学上可接受的盐及其药物组合物。本发明的化合物可用于抑制细菌生长。还描述了使用本发明化合物治疗和/或预防细菌感染的方法以及制备本发明化合物的方法
• Thiol and disulfide-containing agents for increasing meibomian gland lipid secretion
  申请人：Azura Ophthalmics Ltd.

  公开号：US10688122B2

  公开（公告）日：2020-06-23

  Described herein are compositions and methods for the increasing the quantity of lipids secreted from meibomian glands. Such compositions and methods are useful for the treatment of meibomian gland dysfunction and disorders resulting therefrom.

  本文描述了增加睑板腺分泌脂质数量的组合物和方法。这些组合物和方法可用于治疗睑板腺功能障碍和由此引起的疾病。
• Thiol and Disulfide-Containing Agents for Increasing Meibomian Gland Lipid Secretion
  申请人：M.G. Therapeutics, Ltd.

  公开号：US20170087179A1

  公开（公告）日：2017-03-30

  Described herein are compositions and methods for the increasing the quantity of lipids secreted from meibomian glands. Such compositions and methods are useful for the treatment of meibomian gland dysfunction and disorders resulting therefrom.
• TEICOPLANIN ANALOGS AND USES THEREOF
  申请人：Academia Sinica

  公开号：US20170327542A9

  公开（公告）日：2017-11-16

  Described herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting bacterial growth. Methods of using the compounds for treating and/or preventing bacterial infection as well as methods of preparing the compounds are also described.