(2-bromoethyl)(3-chloropropyl)dimethylsilane | 1432587-27-3

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: (2-bromoethyl)(3-chloropropyl)dimethylsilane
• 英文别名: 2-bromoethyl-(3-chloropropyl)-dimethylsilane
• CAS: 1432587-27-3
• 化学式: C₇H₁₆BrClSi
• 分子量: 243.647
• InChiKey: DOONDZDYAMPBON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.72
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (2-bromoethyl)(3-chloropropyl)dimethylsilane 在 三氟甲磺酰胺 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 13.0h， 以32%的产率得到1,3-二(3-氯丙基)-1,1,3,3-四甲基二硅氧烷
  参考文献：
  名称：

  The products of substitution and cyclization in the reaction of (2-bromoethyl)(3-chloropropyl)dimethylsilane with triflamide

  摘要：

  In order to synthesize the first seven-membered N-triflylazasilacycloalkane the reaction of triflamide with (2-bromoethyl)(3-chloropropyl)dimethylsilane was studied. Depending on the reaction conditions bis(3-chloropropyl)tetramethyldisiloxane, 3-trifluoromethylsulfonylaminopropyl(3-chloropropyl)-tetramethyldisiloxane, (2-triflamidoethyl)(3-chloropropyl)dimethylsilane, bis(3-triflamidopropyl)tetramethyldisiloxane, and the target 4,4-dimethyl-1-(trifluoromethylsulfonyl)-1,4-azasilepane have been isolated. In all cases the halogen atom in the beta-bromoethyl group is replaced first. Low-temperature H-1 NMR spectroscopy showed that the prepared seven-membered heterocycle is conformationally flexible.

  DOI：

  10.1134/s1070363213030080
• 作为产物：
  描述：

  3-氯丙基二甲基乙烯基硅烷 在 氢溴酸 、 过氧化苯甲酰 作用下， 以 正己烷 为溶剂， 反应 6.0h， 以83%的产率得到(2-bromoethyl)(3-chloropropyl)dimethylsilane
  参考文献：
  名称：

  The products of substitution and cyclization in the reaction of (2-bromoethyl)(3-chloropropyl)dimethylsilane with triflamide

  摘要：

  In order to synthesize the first seven-membered N-triflylazasilacycloalkane the reaction of triflamide with (2-bromoethyl)(3-chloropropyl)dimethylsilane was studied. Depending on the reaction conditions bis(3-chloropropyl)tetramethyldisiloxane, 3-trifluoromethylsulfonylaminopropyl(3-chloropropyl)-tetramethyldisiloxane, (2-triflamidoethyl)(3-chloropropyl)dimethylsilane, bis(3-triflamidopropyl)tetramethyldisiloxane, and the target 4,4-dimethyl-1-(trifluoromethylsulfonyl)-1,4-azasilepane have been isolated. In all cases the halogen atom in the beta-bromoethyl group is replaced first. Low-temperature H-1 NMR spectroscopy showed that the prepared seven-membered heterocycle is conformationally flexible.

  DOI：

  10.1134/s1070363213030080