ethyl 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)-1-piperazinecarboxylate | 113259-70-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: ethyl 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)-1-piperazinecarboxylate
• 英文别名: ethyl 4-(2-oxo-1,3-dihydroimidazo[4,5-b]quinolin-7-yl)piperazine-1-carboxylate
• CAS: 113259-70-4
• 化学式: C₁₇H₁₉N₅O₃
• 分子量: 341.37
• InChiKey: DTQOVVVAFAIQQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  86.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  ethyl 4-[3-[(Z)-(2,5-dioxoimidazolidin-4-ylidene)methyl]-4-nitrophenyl]piperazine-1-carboxylate 生成 ethyl 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)-1-piperazinecarboxylate
  参考文献：
  名称：

  MEANWELL, NICHOLAS A.;WRIGHT, JOHN J.

  摘要：

  DOI：

文献信息

• 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for
  申请人：Bristol-Myers Company

  公开号：US04701459A1

  公开（公告）日：1987-10-20

  Novel series of 2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolinyl amine derivatives of Formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl; R.sub.2 is hydrogen, lower alkyl, lower alkoxy, halogen; R.sub.3 is hydrogen, lower alkyl; R.sub.4 is hydrogen, lower alkyl, alkanoyl, phenylalkanoyl wherein phenyl is optionally substituted with halogen, lower alkyl, lower alkoxy; R.sub.3 and R.sub.4 are joined together to form morpholinyl, piperidinyl or pyrrolidinyl optionally substituted with --CO.sub.2 R.sub.5 or ##STR2## wherein R.sub.5 is hydrogen or lower alkyl, and R.sub.6 is hydrogen, lower alkyl, cycloalkyl; 4-R.sub.7 -piperazinyl wherein R.sub.7 is --CO.sub.2 R.sub.8 wherein R.sub.8 is lower alkyl, phenyl optionally substituted with up to 2 halogen, lower alkyl or lower alkoxy; phenylalkanoyl of 7 to 10 carbon wherein phenyl is unsubstituted or independently substituted with up to 2 halogen, lower alkyl, lower alkoxy. The compounds are cyclic AMP phosphodiesterase inhibitors and are particularly useful as inhibitors of blood platelet aggregation and/or as cardiotonic agents.

  化合物系列是2,3-二氢-2-氧代-1H-咪唑[4,5-b]喹啉基氨基衍生物，其化学式为##STR1##其中R.sub.1为氢，低碳基；R.sub.2为氢，低碳基，低氧代基，卤素；R.sub.3为氢，低碳基；R.sub.4为氢，低碳基，脂肪酰基，苯基脂肪酰基，其中苯基可选择性地用卤素，低碳基，低氧代基取代；R.sub.3和R.sub.4连接在一起形成吗啉基，哌啶基或吡咯烷基，可选择性地用--CO.sub.2 R.sub.5或##STR2##取代，其中R.sub.5为氢或低碳基，R.sub.6为氢，低碳基，环烷基；4-R.sub.7-哌嗪基，其中R.sub.7为--CO.sub.2 R.sub.8，其中R.sub.8为低碳基，苯基，可选择性地用最多2个卤素，低碳基或低氧代基取代；含有7到10个碳的苯基脂肪酰基，其中苯基未取代或独立取代最多2个卤素，低碳基，低氧代基。这些化合物是环磷酸腺苷磷酸二酯酶抑制剂，特别适用于抑制血小板聚集和/或作为心力衰竭药物。
• Aminoimidazoquinoline derivatives
  申请人：Bristol-Myers Squibb Company

  公开号：EP0252503B1

  公开（公告）日：1992-11-19
• US4701459A
  申请人：——

  公开号：US4701459A

  公开（公告）日：1987-10-20