3-pyrrol-2-yl-3H-isobenzofuran-1-one | 2245-05-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 3-pyrrol-2-yl-3H-isobenzofuran-1-one
• 英文别名: 2-(2-Pyrrolyl)-benzolacton；2-Phthalidyl-pyrrol；2-Phthalidyl-pyrole；3-(1H-pyrrol-2-yl)-3H-2-benzofuran-1-one
• CAS: 2245-05-8
• 化学式: C₁₂H₉NO₂
• 分子量: 199.209
• InChiKey: XUFDOHSWWDKELG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  42.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(Pyrrol-2-ylcarbonyl)benzoic Acid 在 sodium tetrahydroborate 作用下， 以 二乙二醇二甲醚 为溶剂， 生成 3-pyrrol-2-yl-3H-isobenzofuran-1-one
  参考文献：
  名称：

  Keto acids in the pyrrole series

  摘要：

  DOI：

  10.1007/bf00473555

文献信息

• Process for preparing phthalide and naphthalide indicator dyes
  申请人：Polaroid Corporation

  公开号：US03931228A1

  公开（公告）日：1976-01-06

  This invention relates to a process of preparing phthalein indicator dyes including phthalides and naphthalides derived from certain hydroxy-substituted carbocyclic aryl compounds, such as phenols, and from certain N-heterocyclic aryl compounds, such as indoles, and to a process of preparing novel intermediates useful therein. According to the present invention, the selected carbocyclic compound or the selected N-heterocyclic compound is reacted with phthalaldehydic or naphthalaldehydic acid to form the corresponding (na)phthalidyl adduct which is treated with an oxidizing agent to yield the subject intermediates. To prepare the indicator dye, the intermediate, i.e., the oxidation product thus obtained is then reacted with a carbocyclic or heterocyclic aryl compound to yield the corresponding indicator dye. The oxidation products comprising the novel intermediates of the present invention may be dehydro or hydrated (na)phthalidyl adducts.

  本发明涉及一种制备邻苯二酚指示剂染料的过程，包括从某些含羟基的碳环芳基化合物（如酚）和某些含N-杂环芳基化合物（如吲哚）中衍生出的邻苯二酸酐和萘酸酐。本发明中，选定的碳环化合物或选定的N-杂环化合物与邻苯二酸醛或萘酸醛反应，形成相应的（萘）邻苯二酸亚胺加合物，然后用氧化剂处理，得到所述中间体。为制备指示剂染料，即所得到的氧化产物（即中间体）再与碳环或杂环芳基化合物反应，得到相应的指示剂染料。本发明的新型中间体包括脱氢或水合的（萘）邻苯二酸亚胺加合物。
• Protonated indole phthalides and naphthalides
  申请人：Polaroid Corporation

  公开号：US03954799A1

  公开（公告）日：1976-05-04

  This invention relates to protonated compounds of the formula: ##SPC1## Wherein A is a radical selected from ##SPC2## X represents the atoms necessary to complete a ring-closing moiety selected from phthalide and naphthalide; and Z is an anion derived from a protic acid. These compounds are useful as intermediates in the preparation of phthalide and naphthalide indicator dyes.

  本发明涉及公式为：##SPC1##的质子化化合物，其中 A 是从##SPC2##中选择的基团，X代表选择自邻苯二酐和萘酐的环闭合基团所需的原子；Z是从质子酸中衍生的阴离子。这些化合物在制备邻苯二酐和萘酐指示染料的中间体方面具有用途。
• Indole dehydro phthalides and naphthalides
  申请人：Polaroid Corporation

  公开号：US03941807A1

  公开（公告）日：1976-03-02

  This invention relates to a process of preparing phthalein indicator dyes including phthalides and naphthalides derived from certain hydroxy-substituted carbocyclic aryl compounds, such as phenols, and from certain N-heterocyclic aryl compounds, such as indoles, and to a process of preparing novel intermediates useful therein. According to the present invention, the selected carbocyclic compound or the selected N-heterocyclic compound is reacted with phthalaldehydic or naphthalaldehydic acid to form the corresponding (na)phthalidyl adduct which is treated with an oxidizing agent to yield the subject intermediates. To prepare the indicator dye, the intermediate, i.e., the oxidation product thus obtained is then reacted with a carbocyclic or heterocyclic aryl compound to yield the corresponding indicator dye. The oxidation products comprising the novel intermediates of the present invention may be dehydro or hydrated (na)phthalidyl adducts.

  本发明涉及一种制备菲烯指示剂染料的过程，包括从某些羟基取代的碳环芳基化合物（如酚）和某些N-杂环芳基化合物（如吲哚）中衍生出的苯并酐和萘并酐，以及制备有用的新型中间体的过程。根据本发明，所选的碳环化合物或所选的N-杂环化合物与苯并酐或萘并酐酸反应，形成相应的（萘）苯并酐加合物，然后用氧化剂处理以得到所述中间体。为了制备指示剂染料，即用所得的氧化产物，即中间体与碳环或杂环芳基化合物反应，得到相应的指示剂染料。本发明的新型中间体包括脱氢或水合的（萘）苯并酐加合物。
• Indole phthalides and naphthalides
  申请人：Polaroid Corporation

  公开号：US04001278A1

  公开（公告）日：1977-01-04

  This invention relates to a process of preparing phthalein indicator dyes including phthalides and naphthalides derived from certain hydroxy-substituted carbocyclic aryl compounds, such as phenols, and from certain N-heterocyclic aryl compounds, such as indoles, and to a process of preparing novel intermediates useful therein. According to the present invention, the selected carbocyclic compound or the selected N-heterocyclic compound is reacted with phthalaldehydic or naphthalaldehydic acid to form the corresponding (na)phthalidyl adduct which is treated with an oxidizing agent to yield the subject intermediates. To prepare the indicator dye, the intermediate, i.e., the oxidation product thus obtained is then reacted with a carbocyclic or heterocyclic aryl compound to yield the corresponding indicator dye. The oxidation products comprising the novel intermediates of the present invention may be dehydro or hydrated (na)phthalidyl adducts.

  本发明涉及一种制备菲醌指示剂染料的方法，包括由某些羟基取代的碳环芳基化合物（如酚）和某些N-杂环芳基化合物（如吲哚）衍生的菲醇和萘醇，以及制备有用的新中间体的方法。根据本发明，所选的碳环化合物或所选的N-杂环化合物与菲醛酸或萘醛酸反应，形成相应的（na）菲醛基加合物，然后用氧化剂处理以产生所述中间体。为制备指示剂染料，即用所得到的氧化产物即所述中间体与碳环或杂环芳基化合物反应，产生相应的指示剂染料。本发明的新中间体包括脱氢或水合的（na）菲醛基加合物。
• Phthalides and naphthalides
  申请人：Polaroid Corporation

  公开号：US04032545A1

  公开（公告）日：1977-06-28

  This invention relates to a process of preparing phthalein indicator dyes including phthalides and naphthalides derived from certain hydroxy-substituted carbocyclic aryl compounds, such as phenols, and from certain N-heterocyclic aryl compounds, such as indoles, and to a process of preparing novel intermediates useful therein. According to the present invention, the selected carbocyclic compound or the selected N-heterocyclic compound is reacted with phthaladehydic or naphthalaldehydic acid to form the corresponding (na)phthalidyl adduct which is treated with an oxidizing agent to yield the subject intermediates. To prepare the indicator dye, the intermediate, i.e., the oxidation product thus obtained is then reacted with a carbocyclic or heterocyclic aryl compound to yield the corresponding indicator dye. The oxidation products comprising the novel intermediates of the present invention may be dehydro or hydrated (na)phthalidyl adducts.

  本发明涉及一种制备酞菁指示剂染料的方法，包括从某些羟基取代的碳环芳基化合物（如酚）和某些N-杂环芳基化合物（如吲哚）中得到的酞内酰和萘内酰衍生物，以及制备其中有用的新型中间体的方法。根据本发明，选择的碳环化合物或选择的N-杂环化合物与酞内醛或萘内醛酸反应，形成相应的（na）酞内酰基加合物，然后用氧化剂处理以得到所述中间体。为制备指示剂染料，即得到的氧化产物中间体与碳环或杂环芳基化合物反应，得到相应的指示剂染料。本发明的新型中间体包括脱氢或水合的（na）酞内酰基加合物。