2-(cis-2,6-dimethylmorpholinyl)-N-(4-methylphenyl)-6-[4-(2-pyrimidinyl)-1-piperazinyl]-4-pyrimidinamine | 681837-35-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(cis-2,6-dimethylmorpholinyl)-N-(4-methylphenyl)-6-[4-(2-pyrimidinyl)-1-piperazinyl]-4-pyrimidinamine
• 英文别名: 2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-N-(4-methylphenyl)-6-(4-pyrimidin-2-ylpiperazin-1-yl)pyrimidin-4-amine
• CAS: 681837-35-4
• 化学式: C₂₅H₃₂N₈O
• 分子量: 460.582
• InChiKey: NAVCUJPVMYQVOW-BGYRXZFFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  82.5
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• 2,4,6-Triaminopyrimidines for the treatment of depression and/or anxiety
  申请人：——

  公开号：US20040082587A1

  公开（公告）日：2004-04-29

  This invention is directed to pyrimidine derivatives which are selective antagonists for the GalR3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety. This invention also provides a method of treating depression and/or anxiety in a subject which comprises administering to the subject a composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a GalR3 receptor antagonist.

  这项发明涉及选择性拮抗剂对GalR3受体的嘧啶衍生物。该发明提供了一种包含本发明化合物的治疗有效量和药用载体的药物组合物。该发明还提供了一种通过结合本发明化合物的治疗有效量和药用载体制备的药物组合物。该发明还提供了一种制备药物组合物的方法，包括结合本发明化合物的治疗有效量和药用载体。该发明还提供了一种治疗患有抑郁症和/或焦虑症的受试者的方法，包括向受试者投与一定量的本发明化合物以治疗受试者的抑郁症和/或焦虑症。该发明还提供了一种治疗受试者抑郁症和/或焦虑症的方法，包括向受试者投与一种含有药用载体和GalR3受体拮抗剂的组合物的治疗有效量。
• US6936607B2
  申请人：——

  公开号：US6936607B2

  公开（公告）日：2005-08-30