4-(6-(溴甲基)-2-氯噻吩并[3,2-d]嘧啶-4-基)吗啉 | 885698-98-6

分子结构分类

有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物

中文名称

4-(6-(溴甲基)-2-氯噻吩并[3,2-d]嘧啶-4-基)吗啉

中文别名

6-溴甲基-2-氯-4-(吗啉-4-基)-噻吩并[3,2-D]嘧啶

英文名称

4-(6-(bromomethyl)-2-chlorothieno[3,2-d]pyrimidin-4-yl)morpholine

英文别名

6-(bromomethyl)-2-chloro-4-morpholinothieno[3,2-d]pyrimidine；6-bromomethyl-2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine；4-[6-(bromomethyl)-2-chlorothieno[3,2-d]pyrimidin-4-yl]morpholine

CAS

885698-98-6

化学式

C₁₁H₁₁BrClN₃OS

mdl

——

分子量

348.651

InChiKey

DDGJOTNSVPHXNT-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

2.9
重原子数：

18
可旋转键数：

2
环数：

3.0
sp3杂化的碳原子比例：

0.45
拓扑面积：

66.5
氢给体数：

0
氢受体数：

5

安全信息

海关编码：

2934999090

SDS

SDS：053729959eebb55951274bdb985be209

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上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
2-氯-4-(4-吗啉)噻吩并[3,2-d]嘧啶-6-甲醇	(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methanol	885698-97-5	C₁₁H₁₂ClN₃O₂S	285.754
2-氯-4-(4-吗啉)-噻吩并[3,2-d]嘧啶-6-羧醛	2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde	885618-31-5	C₁₁H₁₀ClN₃O₂S	283.738
2-氯-4-(4-吗啉基)噻吩并[3,2-D]嘧啶	2-chloro-4-morpholinothieno[3,2-d]pyrimidine	16234-15-4	C₁₀H₁₀ClN₃OS	255.728

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methanamine	956387-98-7	C₁₁H₁₃ClN₄OS	284.769
1-(2-氯-4-吗啉代噻吩并[3,2-D]吡啶-6-基)-N-甲基甲胺	(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-methylmethanamine	955979-15-4	C₁₂H₁₅ClN₄OS	298.796
——	N-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)propan-1-amine	1235450-53-9	C₁₄H₁₉ClN₄OS	326.85
——	N-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-2-methylpropan-1-amine	1235450-64-2	C₁₅H₂₁ClN₄OS	340.877
——	N-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-2,2-dimethylpropan-1-amine	1235450-50-6	C₁₆H₂₃ClN₄OS	354.904
——	2-chloro-6-((3R,5S)-3,5-dimethyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine	955978-96-8	C₁₇H₂₄ClN₅OS	381.929
——	2-(1-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)propan-2-ol	885699-47-8	C₁₉H₂₇ClN₄O₂S	410.968
——	ethyl 2-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methylamino)pyrimidine-5-carboxylate	1235450-27-7	C₁₈H₁₉ClN₆O₃S	434.906
——	2-chloro-6-[(S)-1-(hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)methyl]-4-morpholin-4-yl-thieno[3,2-d]pyrimidine	1147421-93-9	C₁₈H₂₄ClN₅OS	393.94
——	2-[4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-isobutyramide	955978-93-5	C₂₁H₃₁ClN₆O₂S	467.035
——	8-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1,4-dioxa-8-aza-spiro[4.5]decane	1147421-85-9	C₁₈H₂₃ClN₄O₃S	410.925
——	4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1-(tetrahydro-pyran-4-yl)-piperazin-2-one	1147422-85-2	C₂₀H₂₆ClN₅O₃S	451.977
——	{3-[4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazine-1-sulfonyl]-propyl}-dimethyl-amine	885699-06-9	C₂₀H₃₁ClN₆O₃S₂	503.09
——	[1-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-yl]-methyl-carbamic acid tert-butyl ester	955979-04-1	C₂₂H₃₂ClN₅O₃S	482.047
——	(3S,5R)-4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-3,5-dimethyl-piperazine-1-carboxylic acid tert-butyl ester	885698-99-7	C₂₂H₃₂ClN₅O₃S	482.047
——	2-chloro-6-((2S,6R)-4-methanesulfonyl-2,6-dimethyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine	1032757-69-9	C₁₈H₂₆ClN₅O₃S₂	460.021
——	2-[(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-methyl-amino]-pyrimidine-5-carboxylic acid ethyl ester	1235450-25-5	C₁₉H₂₁ClN₆O₃S	448.933
——	[4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1-methanesulfonyl-piperazin-2-ylmethyl]-dimethyl-amine	956034-61-0	C₁₉H₂₉ClN₆O₃S₂	489.063
——	5-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester	1147421-95-1	C₂₂H₃₀ClN₅O₃S	480.031
——	2-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)isoindoline-1,3-dione	956387-97-6	C₁₉H₁₅ClN₄O₃S	414.872
——	N-(1-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-methyl)pyrrolidin-3-yl)-N-methylmethanesulfonamide	1057369-13-7	C₁₇H₂₄ClN₅O₃S₂	445.994
——	N-[1-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-pyrrolidin-2-ylmethyl]-N-methyl-methanesulfonamide	956034-46-1	C₁₈H₂₆ClN₅O₃S₂	460.021
——	1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-4-methanesulfonyl-piperazin-2-one	956034-01-8	C₁₆H₂₀ClN₅O₄S₂	445.951
——	2-{[(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-methyl-amino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester	956034-53-0	C₂₂H₃₂ClN₅O₃S	482.047
——	(R)-4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-2-isopropyl-piperazine-1-carboxylic acid tert-butyl ester	955979-05-2	C₂₃H₃₄ClN₅O₃S	496.074
——	3-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester	1147421-96-2	C₂₂H₃₀ClN₅O₃S	480.031
——	ethyl 2-(((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(neopentyl)amino)pyrimidine-5-carboxylate	1235450-51-7	C₂₃H₂₉ClN₆O₃S	505.041
——	ethyl 2-(methyl((4-morpholino-2-(pyrimidin-5-yl)thieno[3,2-d]pyrimidine-6-yl)methyl)amino)pyrimidine-5-carboxylate	1235450-83-5	C₂₃H₂₄N₈O₃S	492.561
——	ethyl 2-(methyl((4-morpholino-2-phenylthieno[3,2-d]pyrimidine-6-yl)methyl)amino)pyrimidine-5-carboxylate	1235451-42-9	C₂₅H₂₆N₆O₃S	490.586
——	2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylic acid	1235450-96-0	C₂₄H₂₅N₇O₃S	491.574
——	ethyl 2-(methyl((4-morpholino-2-(pyridin-3-yl)thieno[3,2-d]pyrimidine-6-yl)methyl)amino)pyrimidine-5-carboxylate	1235450-78-8	C₂₄H₂₅N₇O₃S	491.574
——	ethyl 2-(((2-(4-aminophenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate	1235451-07-6	C₂₅H₂₇N₇O₃S	505.6
——	methyl 2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate	1235450-94-8	C₂₅H₂₇N₇O₃S	505.6
——	ethyl 2-(methyl((4-morpholino-2-(1H-pyrrol-3-yl)thieno[3,2-d]pyrimidine-6-yl)methyl)amino)pyrimidine-5-carboxylate	1235451-75-8	C₂₃H₂₅N₇O₃S	479.563
——	2-(((2-(3-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylic acid	1235450-99-3	C₂₄H₂₅N₇O₃S	491.574
——	ethyl 2-(((2-(4-acetamidophenyl)-4-morpholinothieno-[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate	1235451-08-7	C₂₇H₂₉N₇O₄S	547.638
——	ethyl 2-(((2-(4-(acetamidomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidine-6-yl)Methyl)(methyl)amino)pyrimidine-5-carboxylate	1235450-95-9	C₂₈H₃₁N₇O₄S	561.665
——	ethyl 2-(((2-(3,4-diaminophenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate	1235451-59-8	C₂₅H₂₈N₈O₃S	520.615
——	methyl 2-(((2-(3-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate	1235450-97-1	C₂₅H₂₇N₇O₃S	505.6
——	ethyl 2-(((2-(2-amino-4-methylpyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate	1235450-89-1	C₂₄H₂₇N₉O₃S	521.603
——	ethyl 2-(((2-(3-(acetamidomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidine-6-yl)Methyl)(methyl)amino)pyrimidine-5-carboxylate	1235450-98-2	C₂₈H₃₁N₇O₄S	561.665
——	ethyl 2-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methylamino)pyrimidine-5-carboxylate	1235450-28-8	C₂₅H₂₄N₈O₃S	516.583
——	ethyl 2-(((2-(1H-indol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate	1235451-60-1	C₂₇H₂₇N₇O₃S	529.622
——	ethyl 2-(((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate	1235450-26-6	C₂₆H₂₆N₈O₃S	530.61
——	2-[1-[[2-(2-Ethylbenzimidazol-1-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperidin-4-yl]propan-2-ol	1381878-41-6	C₂₈H₃₆N₆O₂S	520.699
——	ethyl 2-(((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(neopentyl)amino)pyrimidine-5-carboxylate	1235450-52-8	C₃₀H₃₄N₈O₃S	586.718
——	ethyl 2-(((2-(6-fluoro-1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate	1235450-49-3	C₂₆H₂₅FN₈O₃S	548.601
——	tert-butyl 4-(6-(((5-(ethoxycarbonyl)pyrimidin-2-yl)(methyl)amino)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)-1H-indole-1-carboxylate	1235451-61-2	C₃₂H₃₅N₇O₅S	629.74

反应信息

作为反应物：

描述：

4-(6-(溴甲基)-2-氯噻吩并[3,2-d]嘧啶-4-基)吗啉在盐酸、 bis-triphenylphosphine-palladium(II) chloride 、氯化亚砜、水、碳酸氢钠、 N,N-二异丙基乙胺作用下，以四氢呋喃、乙醇、水、甲苯、乙腈为溶剂，反应 16.5h，