N-propan-2-yl-N-propan-2-yloxyphosphanylpropan-2-amine | 89437-98-9

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: N-propan-2-yl-N-propan-2-yloxyphosphanylpropan-2-amine
• CAS: 89437-98-9
• 化学式: C₉H₂₂NOP
• 分子量: 191.254
• InChiKey: XEINWYZKGFREQJ-UHFFFAOYSA-N

物化性质

• 沸点：
  57-58 °C(Press: 2.0-2.1 Torr)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  bis(N,N-diisopropylamino)phosphine 、 异丙醇 、 正戊烷 以97%的产率得到
  参考文献：
  名称：

  KING, R. B.;SUNDARAM, P. M., J. ORG. CHEM., 1984, 49, N 10, 1784-1789

  摘要：

  DOI：

文献信息

• [EN] PRODUCTION OF CYCLIC PHOSPHATE, PHOSPHORAMIDATE, THIOPHOSPHATE, AND PHOSPHONATE NUCLEOSIDE COMPOUNDS<br/>[FR] PRODUCTION DE COMPOSÉS CYCLIQUES DE TYPE PHOSPHATE, PHOSPHORAMIDATE, THIOPHOSPHATE, ET PHOSPHONATE NUCLÉOSIDIQUE
  申请人：IDENIX PHARMACEUTICALS INC

  公开号：WO2015095305A1

  公开（公告）日：2015-06-25

  Provided herein are methods for the production of cyclic phosphate, cyclic phosphoramidate, cyclic thiophosphate, and cyclic phosphonate nucleoside compounds. Also provided herein are compounds useful in the production of cyclic phosphate, cyclic phosphoramidate, cyclic thiophosphate, and cyclic phosphonate nucleoside compounds. In certain embodiments, the cyclic phosphate, cyclic phosphoramidate, cyclic thiophosphate, and cyclic phosphonate nucleoside compounds are of Formula (I): wherein: Base, RA, RB, X, R1 and R2 are as defined herein. The cyclic phosphate, cyclic phosphoramidate, cyclic thiophosphate, and cyclic phosphonate nucleoside compounds are useful in the treatment of viral infections, including hepatitis C virus infections in hosts in need thereof.

  本文提供了一种生产环磷酸酯、环磷酰胺酸酯、环硫代磷酸酯和环膦酸酯核苷化合物的方法。本文还提供了在生产环磷酸酯、环磷酰胺酸酯、环硫代磷酸酯和环膦酸酯核苷化合物中有用的化合物。在某些实施例中，环磷酸酯、环磷酰胺酸酯、环硫代磷酸酯和环膦酸酯核苷化合物的化学式为(I)：其中：Base、RA、RB、X、R1和R2如本文所定义。环磷酸酯、环磷酰胺酸酯、环硫代磷酸酯和环膦酸酯核苷化合物在治疗病毒感染方面具有用途，包括治疗需要的宿主体内的丙型肝炎病毒感染。
• King, R. B.; Sadanani, N. D.; Sundaram, P. M., Phosphorus and Sulfur and the Related Elements, 1983, vol. 18, p. 125 - 128
  作者：King, R. B.、Sadanani, N. D.、Sundaram, P. M.

  DOI：——

  日期：——
• Bis(dialkylamino)phosphines
  作者：R. Bruce King、P. M. Sundaram

  DOI：10.1021/jo00184a022

  日期：1984.5
• 2'-CYANO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2696679B1

  公开（公告）日：2017-08-02
• 2'-DICHLORO AND 2'-FLUORO-2'-CHLORO NUCLEOSIDE ANALOGUES FOR HCV INFECTION
  申请人：IDENIX PHARMACEUTICALS LLC

  公开号：US20170198005A1

  公开（公告）日：2017-07-13

  Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-dichloro or 2′-fluoro-2′-chloro nucleoside analogue compounds which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human. In certain embodiments, the compounds are of Formula (I): or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof; wherein each of R A and R B is independently Cl or F, wherein at least one of R A and R B is Cl; and Base, PD and Z are as described herein.