3-chloro-N-(1-methyl-3-(3-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamide | 1415925-39-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-chloro-N-(1-methyl-3-(3-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamide
• 英文别名: 3-chloro-N-[1-methyl-3-[3-(4-methylpiperazin-1-yl)phenyl]pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide
• CAS: 1415925-39-1
• 化学式: C₂₅H₂₆ClN₅O₂S
• 分子量: 496.033
• InChiKey: ANXHVHUDZHOAQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  78.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：GLAXO WELLCOME MFG PTE LTD

  公开号：WO2012170752A1

  公开（公告）日：2012-12-13

  The present invention relates to novel NADPH oxidase II inhibitors and their use in the treatment of diseases mediated by the NADPH oxidase enzymes.

  本发明涉及新型NADPH氧化酶II抑制剂及其在治疗由NADPH氧化酶酶介导的疾病中的应用。
• NOVEL COMPOUNDS
  申请人：Chen Deborah W.

  公开号：US20140155375A1

  公开（公告）日：2014-06-05

  The present invention relates to novel NADPH oxidase II inhibitors and their use in the treatment of diseases mediated by the NADPH oxidase enzymes.

  本发明涉及新型NADPH氧化酶II抑制剂及其在治疗由NADPH氧化酶酶介导的疾病中的应用。
• US8877742B2
  申请人：——

  公开号：US8877742B2

  公开（公告）日：2014-11-04
• [EN] SYMMETRICALLY STRUCTURED QUINAZOLINE DERIVATIVES<br/>[FR] DÉRIVÉS DE QUINAZOLINE À STRUCTURE SYMÉTRIQUE
  申请人：HANMI SCIENCE CO LTD

  公开号：WO2012169785A2

  公开（公告）日：2012-12-13

  The present invention relates to a novel quinazoline derivative and a pharmaceutical composition for preventing or treating cancers, inflammatory diseases, autoimmune diseases, or neurodegenerative disorders comprising same as an active ingredient.