4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)butanamide hydrochloride | 1197155-11-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)butanamide hydrochloride
• 英文别名: 4-[4-(2,3-dichlorophenyl)piperazin-1-yl]-N-(3-oxo-4H-1,4-benzoxazin-6-yl)butanamide;hydrochloride
• CAS: 1197155-11-5
• 化学式: C₂₂H₂₄Cl₂N₄O₃*ClH
• 分子量: 499.824
• InChiKey: OXZIZSAWWNGTOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.29
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  73.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• COMPOSITIONS, SYNTHESIS, AND METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES
  申请人：Bhat Laxminarayan

  公开号：US20100216783A1

  公开（公告）日：2010-08-26

  The present invention provides arylpiperazine derivatives which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder and depression.

  本发明提供了可以优势地用于治疗精神分裂症和相关精神病，如急性躁狂、双相情感障碍、自闭症和抑郁症的芳基哌嗪衍生物。
• Compositions, Synthesis, And Methods Of Using Piperazine Based Antipsychotic Agents
  申请人：Bhat Laxminarayan

  公开号：US20090298819A1

  公开（公告）日：2009-12-03

  The present invention provides novel piperazine derivatives which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder and depression.

  本发明提供了一种新颖的哌嗪衍生物，可以优势地用于治疗精神分裂症和相关精神病，如急性躁狂、双相情感障碍、自闭症和抑郁症。
• ARYLPIPERAZINE DERIVATIVES AND METHODS OF UTILIZING SAME
  申请人：REVIVA PHARMACEUTICALS, INC.

  公开号：US20150166493A1

  公开（公告）日：2015-06-18

  The present invention provides arylpiperazine derivatives which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder, and depression.

  本发明提供了芳基哌嗪衍生物，可优势地用于治疗精神分裂症和相关精神病，例如急性躁狂、双相情感障碍、自闭症和抑郁症。
• METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES
  申请人：Bhat Laxminarayan

  公开号：US20120220574A1

  公开（公告）日：2012-08-30

  The present invention provides arylpiperazine derivatives which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder, and depression.

  本发明提供了芳基哌嗪衍生物，可以优势地用于治疗精神分裂症和相关的精神病，如急性躁狂、双相障碍、自闭症和抑郁症。
• US8207163B2
  申请人：——

  公开号：US8207163B2

  公开（公告）日：2012-06-26