4-(2-hydroxypropan-2-yl)-N-(5-(4-(methylsulfonyl)piperazin-1-yl)thiazolo[5,4-b]pyridin-2-yl)benzamide | 1202054-50-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(2-hydroxypropan-2-yl)-N-(5-(4-(methylsulfonyl)piperazin-1-yl)thiazolo[5,4-b]pyridin-2-yl)benzamide
• 英文别名: 4-(2-hydroxypropan-2-yl)-N-[5-(4-methylsulfonylpiperazin-1-yl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]benzamide
• CAS: 1202054-50-9
• 化学式: C₂₁H₂₅N₅O₄S₂
• 分子量: 475.593
• InChiKey: GBJDIUKGWQGELK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  152
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS
  申请人：Chang Edcon

  公开号：US20090318425A1

  公开（公告）日：2009-12-24

  The present invention relates to apoptosis signal-regulating kinase 1 (“ASK1”) inhibiting compounds of the formula wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

  本发明涉及一种抑制凋亡信号调节激酶1（“ASK1”）的化合物，其化学式如下所示，其中变量如本文所定义。该发明还涉及包括这些化合物的药物组合物、试剂盒和制造物品；制备这些化合物的有用中间体和方法；以及使用这些化合物的方法。
• US8178555B2
  申请人：——

  公开号：US8178555B2

  公开（公告）日：2012-05-15
• [EN] APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS<br/>[FR] INHIBITEURS DE KINASES 1 RÉGULANT LE SIGNAL APOPTOTIQUE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2010008843A1

  公开（公告）日：2010-01-21

  The present invention relates to apoptosis signal-regulating kinase 1 ("ASK1") inhibiting compounds of the formula wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.