triethylammonium 2,3,4-tri-O-benzoyl-6-O-p,p'-dimethoxytrityl-α-D-mannopyranosyl hydrogen phosphonate | 120404-36-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: triethylammonium 2,3,4-tri-O-benzoyl-6-O-p,p'-dimethoxytrityl-α-D-mannopyranosyl hydrogen phosphonate
• 英文别名: 2,3,4-tri-O-benzoyl-6-O-dimethoxytrityl-α-D-mannosyl H-phosphonate；N,N-diethylethanamine;[(2R,3S,4S,5R,6R)-3,4,5-tribenzoyloxy-6-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxan-2-yl]oxyphosphinic acid
• CAS: 120404-36-6
• 化学式: C₆H₁₅N*C₄₈H₄₃O₁₃P
• 分子量: 960.027
• InChiKey: PIXVBRMAKRCBGO-BFNRVNCTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.16
• 重原子数：
  69.0
• 可旋转键数：
  19.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  165.59
• 氢给体数：
  1.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  triethylammonium 2,3,4-tri-O-benzoyl-6-O-p,p'-dimethoxytrityl-α-D-mannopyranosyl hydrogen phosphonate 在 甲醇 、 高氯酸,吡啶 作用下， 以 硝基甲烷 为溶剂， 生成 2,3,4-tri-O-benzoyl-α-D-mannopyranosyl hydrogenphosphonate triethylamine salt
  参考文献：
  名称：

  Cyclic and linear oligo(mannosyl phosphates) from partially protected α-d-mannopyranosyl hydrogenphosphonate

  摘要：

  DOI：

  10.1016/0008-6215(89)80067-9
• 作为产物：
  描述：

  (2S,3S,4R,5R)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,3,4,5-tetrahydroxy-hexanal 在 吡啶 、 咪唑 、 二甲胺 、 三乙胺 、 三氯化磷 作用下， 生成 triethylammonium 2,3,4-tri-O-benzoyl-6-O-p,p'-dimethoxytrityl-α-D-mannopyranosyl hydrogen phosphonate
  参考文献：
  名称：

  Cyclic and linear oligo(mannosyl phosphates) from partially protected α-d-mannopyranosyl hydrogenphosphonate

  摘要：

  DOI：

  10.1016/0008-6215(89)80067-9

文献信息

• The stepwise synthesis of oligo(glycosyl phosphates) via glycosyl hydrogenphosphonates. The chemical synthesis of oligomeric fragments from Hansenula capsulata Y-1842 exophosphomannan and from Escherichia coli K51 capsular antigen
  作者：Andrey V. Nikolaev、Irena A. Ivanova、Vladimir N. Shibaev

  DOI：10.1016/0008-6215(93)80024-9

  日期：1993.4

  A stepwise approach has been used in the syntheses of pentamannosyl tetraphosphate HO-[-6Man(alpha)-PO4-]4-6Man(alpha)-OMe and tetra(N-acetylglucosaminyl) triphosphate HO-[-3GlcNAc(alpha)-PO4]3- 3GlcNAc(beta)-OC6H4NO2, which are fragments of the yeast and bacteria extracellular phosphoglycans. Elongation of the chain was performed with the use of suitably protected glycosyl hydrogenphosphonate derivatives

  逐步方法已用于合成五磷酸五甘露糖基HO-[-6Manα-PO4-]4-6Manα-OMe和四磷酸（N-乙酰氨基葡萄糖基）三磷酸HO-[-3GlcNAcα-PO4 ] 3-3GlcNAcβ-OC6H4NO2，其是酵母和细菌细胞外磷酸聚糖的片段。使用适当保护的糖基氢膦酸酯衍生物连续引入糖基磷酸残基进行链的延长。部分保护的单糖衍生物和低聚嵌段用作羟基组分。
• Parasite glycoconjugates. Part 5. Blockwise approach to oligo(glycosyl phosphates): chemical synthesis of a terminal tris(glycobiosyl phosphate) fragment of Leishmania donovani antigenic lipophosphoglycan
  作者：Andrei V. Nikolaev、Trevor J. Rutherford、Michael A. J. Ferguson、John S. Brimacombe

  DOI：10.1039/p19960001559

  日期：——

  The model tetramannosyl triphosphate 7 and the hexaglycosyl triphosphate 8, which is a terminal fragment of the phosphoglycan portion of Leishmania donovani lipophosphoglycan, have been synthesized. Elongation of the chain was performed using the glycosyl hydrogenphosphonate method to couple together two phosphodiester blocks.

  已经合成了模型四甘露糖基三磷酸 7 和六糖基三磷酸 8（杜氏利什曼原虫脂磷酸聚糖的磷酸聚糖部分的末端片段）。使用糖基膦酸氢法将两个磷酸二酯嵌段偶联在一起进行链的延长。
• NIKOLAEV, A. V.;IVANOVA, I. A.;SHIBAEV, V. N., BIOORGAN. XIMIYA, 16,(1990) N2, S. 1669-1696
  作者：NIKOLAEV, A. V.、IVANOVA, I. A.、SHIBAEV, V. N.

  DOI：——

  日期：——