(2S,6'R)-(7-chloro-4,6-dimethoxybenzofuran-3-one)-2-spiro-1'-(6'-methyl-2-((3,5-dimethyl-4-nitropyrid-2-yl)methyloxy)cyclohex-2'-ene-4'-one) | 1233215-71-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: (2S,6'R)-(7-chloro-4,6-dimethoxybenzofuran-3-one)-2-spiro-1'-(6'-methyl-2-((3,5-dimethyl-4-nitropyrid-2-yl)methyloxy)cyclohex-2'-ene-4'-one)
• 英文别名: (2S,5'R)-7-chloro-3'-[(3,5-dimethyl-4-nitropyridin-2-yl)methoxy]-4,6-dimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione
• CAS: 1233215-71-8
• 化学式: C₂₄H₂₃ClN₂O₈
• 分子量: 502.908
• InChiKey: RTTKLAZJHDSOQW-YYUOZPCZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  130
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• Griseofulvin analogues for the treatment of cancer by inhibition of centrosomal clustering
  申请人：Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

  公开号：EP2204367A1

  公开（公告）日：2010-07-07

  The present invention relates to uses of compounds having a structure as shown by formula (I) for the manufacture of a pharmaceutical composition for the treatment of cancer. Moreover, the present invention encompasses methods of treatment for said diseases.

  本发明涉及具有式（I）所示结构的化合物在制造治疗癌症的药物组合物中的用途。此外，本发明还包括上述疾病的治疗方法。
• GRISEOFULVIN ANALOGUES FOR THE TREATMENT OF CANCER BY INHIBITION OF CENTROSOMAL CLUSTERING
  申请人：Kraemer Alwin

  公开号：US20120035200A1

  公开（公告）日：2012-02-09

  The invention relates to compounds of the formula (I), where the symbols have the meaning given in the specification, for use in a method for treating cancer, to use of these compounds for the manufacture of a pharmaceutical composition for the treatment of cancer, and to methods of treatment for said diseases employing a compound of formula (I).
• US9108941B2
  申请人：——

  公开号：US9108941B2

  公开（公告）日：2015-08-18
• [EN] GRISEOFULVIN ANALOGUES FOR THE TREATMENT OF CANCER BY INHIBITION OF CENTROSOMAL CLUSTERING<br/>[FR] ANALOGUES DE GRISÉOFULVINE POUR LE TRAITEMENT DU CANCER PAR INHIBITION DE L'AGRÉGAT CENTROSOMIAL
  申请人：DKFZ KREBSFORSCHUNGSZENTRUM

  公开号：WO2010072770A2

  公开（公告）日：2010-07-01

  The invention relates to compounds of the formula (I), where the symbols have the meaning given in the specification, for use in a method for treating cancer, to use of these compounds for the manufacture of a pharmaceutical composition for the treatment of cancer, and to methods of treatment for said diseases employing a compound of formula (I).