GO-Y088 | 1233641-52-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: GO-Y088
• 英文别名: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[10-[[1-(2-phenoxyethyl)triazol-4-yl]methoxy]decyl]pentanamide
• CAS: 1233641-52-5
• 化学式: C₃₁H₄₈N₆O₄S
• 分子量: 600.826
• InChiKey: RXTBNXFUNGVJIO-XEVVZDEMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  42
• 可旋转键数：
  22
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  145
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(10-(prop-2-yn-1-yloxy)decyl)pentanamide 、 2-叠氮乙氧基苯 在 copper(l) iodide 作用下， 以 乙腈 为溶剂， 以50%的产率得到GO-Y088
  参考文献：
  名称：

  KSRP/FUBP2 Is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue

  摘要：

  Bis(arylmethylidene)acetone derivatives are an important class of curcumin analogues that exhibit various biological and pharmacological activities. We herein report that GO-Y086, a biotinylated bis(arylmethylidene)acetone, inhibits cancer cell growth. We also show that GO-Y086 specifically interacts with the nuclear protein KSRP/FUBP2 by covalent modification. GO-Y086 markedly suppresses the expression of the c-Myc protein, which plays an important role in cellular proliferation and whose expression is regulated by KSRP/FUBP2.

  DOI：

  10.1021/ml1000454

文献信息

• KSRP/FUBP2 Is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue
  作者：Hiroyuki Yamakoshi、Naoki Kanoh、Chieko Kudo、Atsuko Sato、Kazunori Ueda、Makoto Muroi、Shunsuke Kon、Masanobu Satake、Hisatsugu Ohori、Chikashi Ishioka、Yoshiteru Oshima、Hiroyuki Osada、Natsuko Chiba、Hiroyuki Shibata、Yoshiharu Iwabuchi

  DOI：10.1021/ml1000454

  日期：2010.9.9

  Bis(arylmethylidene)acetone derivatives are an important class of curcumin analogues that exhibit various biological and pharmacological activities. We herein report that GO-Y086, a biotinylated bis(arylmethylidene)acetone, inhibits cancer cell growth. We also show that GO-Y086 specifically interacts with the nuclear protein KSRP/FUBP2 by covalent modification. GO-Y086 markedly suppresses the expression of the c-Myc protein, which plays an important role in cellular proliferation and whose expression is regulated by KSRP/FUBP2.