(3-phenyl-propionyl)-urea | 74867-16-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: (3-phenyl-propionyl)-urea
• 英文别名: (3-Phenyl-propionyl)-harnstoff；N-carbamoyl-3-phenylpropanamide
• CAS: 74867-16-6
• 化学式: C₁₀H₁₂N₂O₂
• 分子量: 192.217
• InChiKey: NQBUUHZMZJSSKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 (3-phenyl-propionyl)-urea
  参考文献：
  名称：

  Solid-Phase Synthesis of Disubstituted N-Acylureas from Resin-Bound Ureas and Acyl Chlorides

  摘要：

  Acylureas (ureides) are valued for their important biological activities. Whereas cyclic acylureas have frequently been the object of solid-phase chemistry, only few reports have focused on the solid-supported preparation of acyclic representatives. We have prepared different types of acylureas on Rink amide resin in three or four steps. The products are either N-acylated (9, 18), N-acylated-N'-allcylated (10, 19), or N-acylated-N-alkylated (22). Characteristic NMR parameters of isomeric acylureas 10, 19, and 22 are discussed.

  DOI：

  10.1021/co100020b

文献信息

• Pharmaceutical composition containing at least a polymer combined with or conjugated to at least a phenylalkylcarboxylic acid salt, conjugate polymers and uses thereof
  申请人：——

  公开号：US20030171333A1

  公开（公告）日：2003-09-11

  The invention concerns a pharmaceutical composition containing at least a polymer associated or conjugated with at least a phenylalkylcarboxylic acid derivative, novel polymers conjugated with at least a phenylalkylcarboxylic acid derivative and their uses in particular in cancer treatment.

  本发明涉及一种药物组成物，该药物组成物至少包含与至少一种苯基烷基羧酸衍生物相关联或共轭的聚合物，以及与至少一种苯基烷基羧酸衍生物共轭的新型聚合物，特别是在癌症治疗中的应用。
• Solid support comprising a functionalized electricity conductor or semiconductor surface, method for preparing same and uses thereof
  申请人：Bureau Christophe

  公开号：US20050272143A1

  公开（公告）日：2005-12-08

  The invention concerns a solid support comprising a functionalized electricity conductor or semiconductor surface coated with a functionalized electrografted organic layer wherein at least 90% of the number of functional groups of interest is accessible. The invention also concerns the method for preparing such a support and uses thereof, in particular as adhesive primer for fixing molecules of interest or objects bearing a complementary function (molecular adhesive).

  本发明涉及一种固体载体，它包括功能化电导体或半导体表面，表面涂有功能化电嫁接有机层，其中至少 90% 的相关功能基团是可触及的。本发明还涉及制备这种支撑物的方法及其用途，特别是用作固定相关分子或具有互补功能的物体（分子粘合剂）的粘合剂底层。
• Anticonvulsant Drugs. II. Some Acylureas¹
  作者：M. A. Spielman、A. O. Geiszler、W. J. Close

  DOI：10.1021/ja01192a063

  日期：1948.12
• COMPOSITION PHARMACEUTIQUE CONTENANT AU MOINS UN POLYMERE ASSOCIE OU CONJUGUE A AU MOINS UN SEL D'UN ACIDE PHENYLALKYLCARBOXYLIQUE, POLYMERES CONJUGUES ET LEURS APPLICATIONS
  申请人：BIODEX

  公开号：EP1289515A1

  公开（公告）日：2003-03-12
• SUPPORT SOLIDE COMPORTANT UNE SURFACE CONDUCTRICE OU SEMI-CONDUCTRICE DE L ELECTRICITE FONCTIONNALISEE, SON PROCEDE DE PREPAR ATION ET SES UTILISATIONS
  申请人：COMMISSARIAT A L'ENERGIE ATOMIQUE

  公开号：EP1551928A1

  公开（公告）日：2005-07-13