[(2R,3R,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3-[[(2R,3R,4R,5R)-3-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-[[(2R,3R,4R,5R)-3-[[(2R,3R,4R,5R)-3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-imidazol-1-ylphosphinic acid | 118533-07-6

分子结构分类

有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸

中文名称

——

中文别名

——

英文名称

[(2R,3R,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3-[[(2R,3R,4R,5R)-3-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-[[(2R,3R,4R,5R)-3-[[(2R,3R,4R,5R)-3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-imidazol-1-ylphosphinic acid

英文别名

——

[(2R,3R,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3-[[(2R,3R,4R,5R)-3-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-[[(2R,3R,4R,5R)-3-[[(2R,3R,4R,5R)-3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-imidazol-1-ylphosphinic acid化学式

CAS

118533-07-6

化学式

C₈₅H₁₁₃N₂₃O₄₈P₆

mdl

——

分子量

2410.8

InChiKey

UYPDWPAUTZXOPU-KHHIXBAKSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

-10.8
重原子数：

162
可旋转键数：

45
环数：

21.0
sp3杂化的碳原子比例：

0.65
拓扑面积：

904
氢给体数：

15
氢受体数：

58

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	[(2R,3R,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-4-(oxan-2-yloxy)-2-(phosphonooxymethyl)oxolan-3-yl] [(2R,3R,4R,5R)-3-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-[[(2R,3R,4R,5R)-3-[[(2R,3R,4R,5R)-3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methyl hydrogen phosphate	118573-16-3	C₈₂H₁₁₁N₂₁O₄₉P₆	2360.74

反应信息

作为反应物：

描述：

[(2R,3R,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3-[[(2R,3R,4R,5R)-3-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-[[(2R,3R,4R,5R)-3-[[(2R,3R,4R,5R)-3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-imidazol-1-ylphosphinic acid 、 2',3'-O-methoxymethylene-N2-(4,4',4''-trimethoxytrityl)-7-methylguanosine-5'-diphosphate 在盐酸作用下，生成

参考文献：

名称：

通过使用适当保护的7-甲基鸟苷二磷酸酯衍生物作为三磷酸酯键形成的供体来合成带帽寡核糖核苷酸的新方法

摘要：

合成了由酸不稳定的4,4'，4''-三甲氧基三苯甲基和甲氧基亚甲基保护的7-甲基鸟苷5'-二磷酸衍生物（），并用作形成三磷酸键的给体组分，得到了封端的六核糖核苷酸，m 7 ģ 5' pppGUAUUA，以改进的收率。

DOI：

10.1016/0040-4039(88)85060-3
作为产物：

描述：

[(2R,3R,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-4-(oxan-2-yloxy)-2-(phosphonooxymethyl)oxolan-3-yl] [(2R,3R,4R,5R)-3-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-[[(2R,3R,4R,5R)-3-[[(2R,3R,4R,5R)-3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methyl hydrogen phosphate 生成 [(2R,3R,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3-[[(2R,3R,4R,5R)-3-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-[[(2R,3R,4R,5R)-3-[[(2R,3R,4R,5R)-3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-(oxan-2-yloxy)oxolan-2-yl]methoxy-imidazol-1-ylphosphinic acid

参考文献：

名称：

IWASE, REIKO;SEKINE, MITSUO;HATA, TSUJIAKI;MIURA, KIN-ICHIRO, TETRAHEDRON LETT., 29,(1988) N 24, 2969-2972

摘要：

DOI：

点击查看最新优质反应信息

文献信息

SEKINE, MITSUO;IWASE, REIKO;HATA, TSUJIAKI;MIURA, KIN-ICHIRO, J. CHEM. SOC. PERKIN TRANS. PT 1,(1989) N, C. 969-978

作者：SEKINE, MITSUO、IWASE, REIKO、HATA, TSUJIAKI、MIURA, KIN-ICHIRO

DOI：——

日期：——

同类化合物

黄苷5'-(四氢三磷酸酯)三钠盐黄苷3',5'-环单磷酸酯黄苷-5'-三磷酸酯鸟苷酸鸟苷酰-(3'-5')-3'-鸟苷酸鸟苷三磷酸锂鸟苷5'-三磷酸酯锰盐鸟苷5'-[氢(膦酰甲基)膦酸酯]钠盐鸟苷3'-(三氢二磷酸酯),5'-(三氢二磷酸酯) 鸟苷2’,3’-环单磷酸酯三乙胺盐鸟苷-5’-二磷酸鸟苷-5'-三磷酸二钠盐鸟苷-5'-O-(2-硫代三磷酸)三锂盐鸟苷-3,5-环单磷酸单钠盐鸟苷-3',5'-环单硫代磷酸酯 Rp-异构体钠盐鸟苷 5'-(四氢三磷酸酯-P''-32P) 鸟苷 5'-(四氢 5-硫代三磷酸酯) 鸟氨酸,乙基酯(9CI) 鸟嘌呤核糖苷-3’,5’-环磷酸酯铁-腺苷三磷酸酯络合物钠(4aR,6R,7R,7aR)-6-{6-氨基-8-[(4-氯苯基)硫基]-9H-嘌呤-9-基}-7-甲氧基四氢-4H-呋喃并[3,2-d][1,3,2]二氧杂环己膦烷-2-醇2-氧化物水合物(1:1:1) 辅酶A二硫醚八锂盐辅酶 A 钠盐水合物辅酶 A 葡甲胺环腺苷酸苯基新戊基酮三甲基甲硅烷基烯醇醚苯乙酰胺,a-羟基-3,5-二硝基- 苯乙酰胺,4-溴-3-甲基- 苯丙酸,4-[3-(10,11-二氢-10-羰基-5H-二苯并[b,f]吖庚英-5-基)丙氧基]-a-丙氧基- 腺苷酸基琥珀酸腺苷酰基亚胺二磷酸四锂盐腺苷酰-(2'-5')-腺苷酰-(2'-5')腺苷腺苷环磷酸酯腺苷焦磷酸酯-葡萄糖腺苷四磷酸吡哆醛腺苷三磷酸酯铜盐腺苷三磷酸酯gamma-4-叠氮基苯胺腺苷三磷酸酯-尿苷单磷酸酯腺苷三磷酸酯-gamma-4-(N-2-氯乙基-N-甲基氨基)苄基酰胺腺苷三磷酸酯-gamma 酰胺腺苷三磷酸酯 gamma-苯胺腺苷三磷酸吡哆醛腺苷5`-三磷酸酯二(三羟甲基胺)盐二水合物腺苷5'-五磷酸酯腺苷5'-三磷酸酯3'-二磷酸酯腺苷5'-[氢[[羟基(膦酰氧基)亚膦酰]甲基]膦酸酯] 腺苷5'-O-(2-硫代三磷酸酯) 腺苷5'-(氢((羟基((羟基(膦酰氧基)亚膦酰)氧基)亚膦酰)甲基)膦酸酯) 腺苷5'-(三氢二磷酸酯)镁盐腺苷5'-(O-甲基磷酸酯)