(1S,4S)-tert-butyl 5-(4-(3-pyrazin-2-ylureido)quinolin-6-yl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate | 1192362-04-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (1S,4S)-tert-butyl 5-(4-(3-pyrazin-2-ylureido)quinolin-6-yl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
• 英文别名: tert-butyl (1S,4S)-5-[4-(pyrazin-2-ylcarbamoylamino)quinolin-6-yl]-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
• CAS: 1192362-04-1
• 化学式: C₂₄H₂₇N₇O₃
• 分子量: 461.523
• InChiKey: LKMODCHPXJKKEV-IRXDYDNUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• 1-(7-(HEXAHYDROPYRROLO [3, 4-C] PYRROL-2 (1H)-YL) QUINOLIN-4-YL) -3- (PYRAZIN-2-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK-3)
  申请人：Turner Sean Colm

  公开号：US20110105528A1

  公开（公告）日：2011-05-05

  The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

  本发明涉及一种新型杂环化合物，该化合物对于抑制糖原合酶激酶3（GSK-3）具有有用性，制备该化合物的方法，含有该化合物的组合物，以及使用该化合物的治疗方法。
• 1- (7-(HEXAHYDROPYRROLO [3, 4-C]PYRROL-2 (1H) -YL) QUIN0LIN-4-YL) -3- (PYRAZIN-2-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK-3) INHIBITORS
  申请人：Abbott GmbH & Co. KG

  公开号：EP2297154B1

  公开（公告）日：2013-04-03
• 1- (7-(HEXAHYDROPYRROLO [3, 4-C]PYRROL-2 (1H) -YL) QUIN0LIN-4-YL) -3- (PYRAZIN-2-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK-3)
  申请人：Abbott GmbH & Co. KG

  公开号：EP2297154A1

  公开（公告）日：2011-03-23
• US8455648B2
  申请人：——

  公开号：US8455648B2

  公开（公告）日：2013-06-04
• [EN] 1- (7-(HEXAHYDROPYRROLO [3, 4-C] PYRROL-2 (1H) -YL) QUIN0LIN-4-YL) -3- (PYRAZIN-2-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK-3)<br/>[FR] DÉRIVÉS DE 1-(7-(HEXAHYDROPYRROLO[3,4-C]PYRROL-2(1H)-YL)QUINOLÉIN-4-YL)-3-(PYRAZIN-2-YL)URÉE ET COMPOSÉS APPARENTÉS EN TANT QU'INHIBITEURS DE GLYCOGÈNE SYNTHASE KINASE 3 (GSK-3)
  申请人：ABBOTT GMBH & CO KG

  公开号：WO2009130317A1

  公开（公告）日：2009-10-29

  The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.