7-bromo-2-(4-methylpiperazin-1-yl)quinoxaline | 1116093-40-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 7-bromo-2-(4-methylpiperazin-1-yl)quinoxaline
• CAS: 1116093-40-3
• 化学式: C₁₃H₁₅BrN₄
• 分子量: 307.193
• InChiKey: DKHSXYMANURRID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  32.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS USEFUL AS IMMUNOMODULATORS<br/>[FR] COMPOSÉS UTILES EN TANT QU'IMMUNOMODULATEURS
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2018118848A1

  公开（公告）日：2018-06-28

  The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

  本公开涉及通常用作免疫调节剂的化合物。本文提供了包含这些化合物的化合物、组合物以及它们的使用方法。该公开进一步涉及包含至少一种根据本公开的化合物的药物组合物，用于治疗各种疾病，包括癌症和传染病。
• [EN] HETEROCYCLIC CARBOXYLIC ACID AMIDES AS PDK1 INIHIBITORS<br/>[FR] AMIDES D'ACIDE CARBOXYLIQUE HÉTÉROCYCLIQUES COMME INHIBITEURS DE PDK1
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2011131741A1

  公开（公告）日：2011-10-27

  The present invention encompasses compounds of general formula (1) wherein the groups R1 to R4, Qa, Qb, QH, L and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and their use as medicaments.

  本发明涵盖了通式（1）中的化合物，其中基团R1至R4、Qa、Qb、QH、L和n的定义如权利要求书中所述，这些化合物适用于治疗以细胞过度或异常增殖为特征的疾病，包括含有这些化合物的药物制剂以及它们作为药物的使用。
• NEW CHEMICAL COMPOUNDS
  申请人：Engelhardt Harald

  公开号：US20120094976A1

  公开（公告）日：2012-04-19

  The present invention encompasses compounds of general formula (1) wherein the groups R 1 to R 4 , Q a , Q b , Q H , L and n are defined as in claim 1 , which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and their use as medicaments.

  本发明涵盖了一般式（1）中的化合物，其中基团R1至R4、Qa、Qb、QH、L和n的定义如权利要求书中所述，这些化合物适用于治疗由细胞过度或异常增殖特征的疾病，包括含有这些化合物的药物制剂以及它们作为药物的用途。
• Compounds useful as immunomodulators
  申请人：Bristol-Myers Squibb Company

  公开号：US10882844B2

  公开（公告）日：2021-01-05

  The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

  本公开内容一般涉及可用作免疫调节剂的化合物。本文提供了化合物、包含此类化合物的组合物及其使用方法。本公开进一步涉及包含至少一种根据本公开的化合物的药物组合物，这些组合物可用于治疗各种疾病，包括癌症和传染性疾病。
• Heterocyclic carboxylic acid amides as PDK1 inihibitors
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2560967B1

  公开（公告）日：2017-12-20