cis-[(1R,2R)-N¹-cyclohexyl-1,2-diaminocyclohexane-N,N'][(+)-camphorato-O,O']platinum(II) | 1428944-37-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: cis-[(1R,2R)-N¹-cyclohexyl-1,2-diaminocyclohexane-N,N'][(+)-camphorato-O,O']platinum(II)
• CAS: 1428944-37-9
• 化学式: C₂₂H₃₆N₂O₄Pt
• 分子量: 587.619
• InChiKey: HRMCKKUBNZAGHJ-LZVQJMNNSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  以 水 为溶剂， 反应 30.0h， 生成 cis-[(1R,2R)-N¹-cyclohexyl-1,2-diaminocyclohexane-N,N'][(+)-camphorato-O,O']platinum(II)
  参考文献：
  名称：

  Synthesis and biological evaluation of platinum(II) complexes containing (1R,2R)-N1-alkyl-1,2-diaminocyclohexane and D-(+)-camphorate ligands

  摘要：

  Five platinum(II) complexes with N-monoalkyl derivatives of 1R,2R-diaminocyclohexane as ligands and D-(+)-camphorate anion as leaving group have been synthesized and characterized by elemental analysis, IR, H-1 NMR, ESI-MS, and HRMS spectra. All complexes were evaluated for their in vitro cytotoxicity against four human tumor cell lines and most of them showed promising cytotoxic activity, especially compounds 3 and 4 with branched alkyl substituent at one of nitrogen atoms. Preliminary mechanism study by flow cytometry and agarose gel electrophoresis was also carried out in comparison with cisplatin and oxaliplatin. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.10.011