1,9-dimethyl-7-(4-methylpiperazin-1-yl)phenothiazin-3-one | 1400810-63-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,9-dimethyl-7-(4-methylpiperazin-1-yl)phenothiazin-3-one
• 英文别名: 1,9-dimethyl-7-(4-methylpiperazin-1-yl)-3H-phenothiazin-3-one
• CAS: 1400810-63-0
• 化学式: C₁₉H₂₁N₃OS
• 分子量: 339.461
• InChiKey: LELRJURAOZYWIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  61.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Antiviral Compounds
  申请人：Hurt Clarence

  公开号：US20120238543A1

  公开（公告）日：2012-09-20

  Novel compounds, methods, and compositions for treating various viral infections are described. In some embodiments the novel compounds of the invention are 3-oxo-phenothiazine derivatives; more specific embodiments include 3-oxo-phenothiazine derivatives having substituents at the 1-, 7-, and 9-positions of the phenothiazine parent ring. In other embodiments, the invention provides compositions and methods for treating viral infections, especially HIV.

  描述了用于治疗各种病毒感染的新型化合物、方法和组合物。在某些实施例中，本发明的新型化合物是3-氧代苯并噻嗪衍生物；更具体的实施例包括在苯并噻嗪母环的1-、7-和9-位置具有取代基的3-氧代苯并噻嗪衍生物。在其他实施例中，本发明提供了用于治疗病毒感染，特别是HIV的组合物和方法。
• ANTIVIRAL COMPOUNDS
  申请人：Prosetta Antiviral Inc.

  公开号：EP2699241A1

  公开（公告）日：2014-02-26
• US8759336B2
  申请人：——

  公开号：US8759336B2

  公开（公告）日：2014-06-24
• US8828986B2
  申请人：——

  公开号：US8828986B2

  公开（公告）日：2014-09-09
• [EN] ANTIVIRAL TREATMENTS<br/>[FR] TRAITEMENTS ANTIVIRAUX
  申请人：PROSETTA ANTIVIRAL INC

  公开号：WO2012125983A1

  公开（公告）日：2012-09-20

  Novel compounds, methods, and compositions for treating various viral infections are described. In some embodiments the novel compounds of the invention are 3-oxo- phenothiazine derivatives; more specific embodiments include 3-oxo-phenothiazine derivatives having substituents at the 1-, 7-, and 9-positions of the phenothiazine parent ring. In other embodiments, the invention provides compositions and methods for treating viral infections, especially HIV.