L-(2R,3R)-4-[4-(3-chlorophenyl)-piperazin-1-yl]-2,3-dihydroxy-N-naphthalen-2-yl-4-oxo-butyramide | 1040283-01-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: L-(2R,3R)-4-[4-(3-chlorophenyl)-piperazin-1-yl]-2,3-dihydroxy-N-naphthalen-2-yl-4-oxo-butyramide
• 英文别名: (2R,3R)-4-[4-(3-chlorophenyl)piperazin-1-yl]-2,3-dihydroxy-N-naphthalen-2-yl-4-oxobutanamide
• CAS: 1040283-01-9
• 化学式: C₂₄H₂₄ClN₃O₄
• 分子量: 453.925
• InChiKey: FXFLKMYVERUHAO-FGZHOGPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  93.1
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• DERIVATIVES OF SUBSTITUTED TARTARIC ACID AND USAGE FOR PREPARING BETA-SECRETASE INHIBITORS
  申请人：Li Song

  公开号：US20100331345A1

  公开（公告）日：2010-12-30

  The present invention relates to compounds represented by formula (I), or isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof: in which each substituent of formula (I) is as defined in the specification. The present invention also relates to preparation methods of compounds represented by formula (I), a pharmaceutical composition comprising compounds represented by formula (I) and usage of compounds represented by formula (I) for treating chronic neurodegenerative diseases such as Alzheimer's disease and other diseases induced by aggregation or deposition of β-amyloid peptide.

  本发明涉及由式(I)表示的化合物，或其异构体、前药、药用可接受的盐、溶剂合物或水合物：其中式(I)的每个取代基如规范中所定义。本发明还涉及由式(I)表示的化合物的制备方法，包括由式(I)表示的化合物的药物组合物以及利用由式(I)表示的化合物治疗慢性神经退行性疾病，如阿尔茨海默病和其他由β-淀粉样蛋白聚集或沉积引起的疾病。
• DERIVATES OF SUBSTITUTED TARTARIC AICD AND USAGE FOR PREPARATING BETA SECRETASE INHIBITORS
  申请人：Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

  公开号：EP2116526B1

  公开（公告）日：2018-04-18
• US8268884B2
  申请人：——

  公开号：US8268884B2

  公开（公告）日：2012-09-18