5-oxo-4-[2-(phenylcarbamoyl)ethyl]oxazolidine-3-carboxylic acid benzyl ester | 848215-07-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-oxo-4-[2-(phenylcarbamoyl)ethyl]oxazolidine-3-carboxylic acid benzyl ester
• CAS: 848215-07-6
• 化学式: C₂₀H₂₀N₂O₅
• 分子量: 368.389
• InChiKey: NSTCJQAPLFWTRO-KRWDZBQOSA-N

物化性质

• 沸点：
  647.7±50.0 °C(Predicted)
• 密度：
  1.312±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.93
• 重原子数：
  27.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  84.94
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  5-oxo-4-[2-(phenylcarbamoyl)ethyl]oxazolidine-3-carboxylic acid benzyl ester 在 palladium on activated charcoal lithium hydroxide 、 氢气 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 0.5h， 生成 N-苯基谷氨酰胺
  参考文献：
  名称：

  Nγ-Aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site

  摘要：

  Analogues of L-glutamine were designed and synthesized to test a hydrogen-bond hypothesis between ligand and neutral amino acid transporter ASCT2. The key design feature contains a substituted phenyl ring on the amide nitrogen that contains electron withdrawing and electron donating groups that alter the pK(a) of the amide NH. Through this study a preliminary binding site map has been developed, and a potent commercially available competitive inhibitor of the ASCT2 transporter has been identified. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.11.028
• 作为产物：
  描述：

  (S)-(+)-3-(苄氧基羰基)-5-氧代-4-噁唑啉丙酸 在 吡啶 、 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 0.75h， 生成 5-oxo-4-[2-(phenylcarbamoyl)ethyl]oxazolidine-3-carboxylic acid benzyl ester
  参考文献：
  名称：

  Nγ-Aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site

  摘要：

  Analogues of L-glutamine were designed and synthesized to test a hydrogen-bond hypothesis between ligand and neutral amino acid transporter ASCT2. The key design feature contains a substituted phenyl ring on the amide nitrogen that contains electron withdrawing and electron donating groups that alter the pK(a) of the amide NH. Through this study a preliminary binding site map has been developed, and a potent commercially available competitive inhibitor of the ASCT2 transporter has been identified. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.11.028