(S)-1-benzyl-7-chloro-3-(4-hydroxy-phenyl)-3-methyl-5-piperazin-1-yl-1H-quinoline-2,4-dione | 929116-82-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (S)-1-benzyl-7-chloro-3-(4-hydroxy-phenyl)-3-methyl-5-piperazin-1-yl-1H-quinoline-2,4-dione
• 英文别名: 9FN27TX5ZE；(3S)-1-benzyl-7-chloro-3-(4-hydroxyphenyl)-3-methyl-5-piperazin-1-ylquinoline-2,4-dione
• CAS: 929116-82-5
• 化学式: C₂₇H₂₆ClN₃O₃
• 分子量: 475.975
• InChiKey: QFOBHYKKXFZEPW-MHZLTWQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  72.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• N-Substituted-1H-Quinoline-2,4-Diones, Preparation Method Thereof, And Pharmaceutical Composition Containing The Same
  申请人：Seong Churlmin

  公开号：US20080275058A1

  公开（公告）日：2008-11-06

  The present invention relates to compounds of N-substituted -1H-quinoline-2,4-diones acting as a 5HT6 receptor antagonist, a preparation method thereof, and a pharmaceutical composition containing the same for treatment of the central nervous system disorders. The compounds of N-substituted-1H-quinoline-2,4-diones according to the present invention have excellent binding affinity for the 5HT6 receptor and excellent selectivity for the 5HT6 receptor over other receptors. Also, the compounds reverse a disruption of PPI by methamphetamine and don't show rotatod deficit in mice. Thereof the compounds according to the present invention may be valuably used for treatment if a 5HT6 receptor relating disorder

  本发明涉及N-取代-1H-喹啉-2,4-二酮化合物，其作为5HT6受体拮抗剂，其制备方法以及含有该化合物的制剂，用于治疗中枢神经系统疾病。根据本发明的N-取代-1H-喹啉-2,4-二酮化合物具有优异的5HT6受体结合亲和力和对5HT6受体的优异选择性。此外，这些化合物能够逆转甲基苯丙胺引起的PPI破坏，并且在小鼠中不表现出旋转缺陷。因此，根据本发明的化合物可以有价值地用于治疗与5HT6受体相关的疾病。