2'-deoxyadenosine-5'-tetraphosphate | 210532-81-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: 2'-deoxyadenosine-5'-tetraphosphate
• 英文别名: P-P-P-P-dAdo；[[(2R,3S,5R)-5-(6-aminopurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [hydroxy(phosphonooxy)phosphoryl] hydrogen phosphate
• CAS: 210532-81-3
• 化学式: C₁₀H₁₇N₅O₁₅P₄
• 分子量: 571.165
• InChiKey: WKJSDHFPEOIZTR-RRKCRQDMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.5
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  305
• 氢给体数：
  7
• 氢受体数：
  19

反应信息

• 作为产物：
  描述：

  在 三正丁胺 、 tris[tributylammonium] triphosphate 作用下， 以 乙腈 为溶剂， 生成 2'-deoxyadenosine-5'-tetraphosphate
  参考文献：
  名称：

  A new, facile, and protection-free one-pot chemical synthesis of 2′-deoxynucleoside-5′-tetraphosphates

  摘要：

  A new straight forward, reliable, and an efficient method for the chemical synthesis of 2'-deoxynucleoside-5'-tetraphosphate is reported. The present 'one-pot, three step' synthetic strategy involves the monophosphorylation of nucleoside followed by reaction with tris-(tri-n-butylammonium) triphosphate and hydrolysis of the putative cyclic tetrametaphosphate intermediate to provide the corresponding 2'-deoxynucleoside-5'-tetraphosphate in moderate yield with high purity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.08.071

文献信息

• LARGE STOKES SHIFT DYES
  申请人：Life Technologies Corporation

  公开号：EP2396318A2

  公开（公告）日：2011-12-21
• COMPOSITIONS AND METHODS FOR IMPROVING THE THERMAL STABILITY OF NUCLEIC ACID AMPLIFICATION REAGENTS
  申请人：Roche Molecular Systems, Inc.

  公开号：US20180363044A1

  公开（公告）日：2018-12-20

  The present invention provides for stable nucleotide reagents used for nucleic acid amplification by PCR and RT-PCR (Reverse Transcriptase-PCR) that comprises nucleoside polyphosphates having four or more phosphates. The present invention also provides for methods for using the nucleoside polyphosphates having four or more phosphates for detecting the presence or absence of a target nucleic acid sequence in a sample in an amplification reaction.
• METHODS OF SYNTHESIZING OLIGONUCLEOTIDES USING TETHERED NUCLEOTIDES
  申请人：Twist Bioscience Corporation

  公开号：US20220145289A1

  公开（公告）日：2022-05-12

  Disclosed herein are methods and compositions comprising a polymerase and a phosphorylated nucleoside, wherein the polymerase and the nucleoside are covalently linked by a cleavable linker at the terminal phosphate group. Further disclosed herein are enzymatic polynucleotide synthesis using polymerase and nucleotide conjugation strategies.
• US9624424B2
  申请人：——

  公开号：US9624424B2

  公开（公告）日：2017-04-18
• [EN] LARGE STOKES SHIFT DYES<br/>[FR] COLORANTS À DÉVIATION DE STOKES ÉLEVÉE
  申请人：LIFE TECHNOLOGIES CORP

  公开号：WO2010093726A2

  公开（公告）日：2010-08-19

  Provided herein are heptamethine cyanine dyes having a large Stokes shift, and the salts and conjugates thereof. Also provided are methods of using and making such large Stokes shift dyes as fluorescence resonance energy transfer (FRET) acceptors or donors.