Phosphoric acid mono-{(2R,3S,4R,5R)-3,4-dihydroxy-5-[2-(4-methoxy-benzyl)-6-oxo-1,6-dihydro-purin-9-yl]-tetrahydro-furan-2-ylmethyl} ester; compound with ammonia | 88868-87-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: Phosphoric acid mono-{(2R,3S,4R,5R)-3,4-dihydroxy-5-[2-(4-methoxy-benzyl)-6-oxo-1,6-dihydro-purin-9-yl]-tetrahydro-furan-2-ylmethyl} ester; compound with ammonia
• CAS: 88868-87-5
• 化学式: C₁₈H₂₁N₄O₉P*2H₃N
• 分子量: 502.421
• InChiKey: BLGZQIZJGAWVPJ-SINQMCSXSA-N

反应信息

• 作为产物：
  描述：

  9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(4-methoxy-benzyl)-1,9-dihydro-purin-6-one 在 磷酸三甲酯 、 三氯氧磷 作用下， 反应 5.0h， 以53%的产率得到Phosphoric acid mono-{(2R,3S,4R,5R)-3,4-dihydroxy-5-[2-(4-methoxy-benzyl)-6-oxo-1,6-dihydro-purin-9-yl]-tetrahydro-furan-2-ylmethyl} ester; compound with ammonia
  参考文献：
  名称：

  Inhibitors of inosinic acid dehydrogenase. 2-Substituted inosinic acids

  摘要：

  A series of 2-substituted inosine monophosphate (IMP) and inosine derivatives were synthesized and tested for inhibitory activity against IMP dehydrogenase from Escherichia coli. All of the IMP analogues that possessed electron-withdrawing substituents on the phenyl ring of a benzylthio group placed at the 2-position of IMP showed strong inhibition, which was competitive with IMP. No evidence of hydrophobic interactions of the 2-substituent with the enzyme was observed.

  DOI：

  10.1021/jm00370a003