7-Azaspiro[3.5]nonan-2-amine dihydrochloride | 2940948-69-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 7-Azaspiro[3.5]nonan-2-amine dihydrochloride
• 英文别名: 7-azaspiro[3.5]nonan-2-amine;dihydrochloride
• CAS: 2940948-69-4
• 化学式: C8H18Cl2N2
• 分子量: 213.15
• InChiKey: IMPWXFCNDVNLHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.32
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  4
• 氢受体数：
  2

文献信息

• LSD1 inhibitors and medical uses thereof
  申请人：Constellation Pharmaceuticals, Inc.

  公开号：US10517849B2

  公开（公告）日：2019-12-31

  Provided are novel compounds of Formula (I or Ia′): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I or Ia′), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.

  本发明提供了式(I或Ia′)的新型化合物：及其药学上可接受的盐类，可用于治疗与LSD1相关的各种疾病、失调或病症。还提供了包含式（I或Ia′）新型化合物及其药学上可接受的盐的药物组合物，以及它们用于治疗一种或多种与LSD1相关的疾病、失调或病症的方法。
• LSD1 INHIBITORS AND MEDICAL USES THEREOF
  申请人：Constellation Pharmaceuticals, Inc.

  公开号：US20190274998A1

  公开（公告）日：2019-09-12

  Provided are novel compounds of Formula (I or Ia′): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I or Ia′), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.