2-[[4-(3-Aminoanilino)-6-[4-[4,6-bis(3-aminoanilino)-1,3,5-triazin-2-yl]piperazin-1-yl]-1,3,5-triazin-2-yl]amino]ethanol | 852673-14-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[[4-(3-Aminoanilino)-6-[4-[4,6-bis(3-aminoanilino)-1,3,5-triazin-2-yl]piperazin-1-yl]-1,3,5-triazin-2-yl]amino]ethanol
• CAS: 852673-14-4
• 化学式: C₃₀H₃₅N₁₅O
• 分子量: 621.708
• InChiKey: GLGVNQHZXNWSPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  46
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  230
• 氢给体数：
  8
• 氢受体数：
  16

文献信息

• Triazine dimers for the treatment of autoimmune diseases
  申请人：Penney Christopher

  公开号：US20070149528A1

  公开（公告）日：2007-06-28

  Compounds containing two mono- or disubstituted triazine rings covalently linked by an organic linker, but not linked directly to each other, may be used to treat autoimmune diseases. Autoimmune diseases which are amenable to treatment with compounds of this invention include rheumatoid arthritis, systemic lupus erythematosus (SLE), idiopathic (immune) thrombocytopenia (ITP), glomerulonephritis and vasculitis. The present invention also relates to reducing drug toxicity which often accompanies traditional therapies for autoimmune diseases. The compounds may also be used to bind antibody in vitro or ex vivo.
• US7683061B2
  申请人：——

  公开号：US7683061B2

  公开（公告）日：2010-03-23