4-(4-bromo-butoxy)-2,2-dimethyl-benzofuran-3-one | 753013-64-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 4-(4-bromo-butoxy)-2,2-dimethyl-benzofuran-3-one
• 英文别名: 4-(4-Bromobutoxy)-2,2-dimethyl-1-benzofuran-3-one
• CAS: 753013-64-8
• 化学式: C₁₄H₁₇BrO₃
• 分子量: 313.191
• InChiKey: IYWUMSJKRJABKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] NOVEL HYDROXYCOUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS WITH IMPROVED BIOLOGICAL ACTIVITY IN CELLULAR ASSAYS AND IMPROVED STABILITY<br/>[FR] NOUVEAUX DERIVES D'HYDROXYCOUMARANONE UTILISES EN TANT QU'AGENTS ANTITUMORAUX ET ANTIMETASTATIQUES A ACTIVITE BIOLOGIQUE AMELIOREE DANS DES DOSAGES CELLULAIRES ET A STABILITE AMELIOREE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004076444A2

  公开（公告）日：2004-09-10

  The present invention relates to new compounds of the general formula (I) or (II), their pharmaceutically acceptable salts as well as their enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above mentioned compounds as uPA receptor antagonists and therefore in the control or prevention of corresponding illnesses and disorders as outlined herein; or in the manufacture of corresponding medicaments.