4-(2-Hydroxyethyl)-1-piperazinesulfonic acid | 146511-06-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(2-Hydroxyethyl)-1-piperazinesulfonic acid
• 英文别名: 4-(2-hydroxyethyl)piperazine-1-sulfonic acid
• CAS: 146511-06-0
• 化学式: C₆H₁₄N₂O₄S
• 分子量: 210.25
• InChiKey: CVSDWRGWBWLCLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  89.5
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] PYRIMIDINE SULPHONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS<br/>[FR] COMPOSES
  申请人：ASTRAZENECA AB

  公开号：WO2006024823A1

  公开（公告）日：2006-03-09

  A compound of formula (1), or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof and pharmaceutical compositions comprising these, all for use in the treatment of chemokine mediated diseases and disorders.

  公式（1）的化合物，或其药用可接受的盐、溶剂化合物或体内水解酯，以及包括这些化合物的药物组合物，均用于治疗趋化因子介导的疾病和障碍。
• Polypeptides and biosynthetic pathways for the production of monatin and its precursors
  申请人：Hicks M. Paula

  公开号：US20050282260A1

  公开（公告）日：2005-12-22

  Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.

  本文提供了用于从葡萄糖、色氨酸、吲哚-3-乳酸、吲哚-3-丙酮酸和2-羟基2-(吲哚-3-基甲基)-4-酮戊二酸制备莫纳汀的方法和组合物。还揭示了制备吲哚-3-丙酮酸和2-羟基2-(吲哚-3-基甲基)-4-酮戊二酸中间体的方法。提供的组合物包括核酸分子、多肽、化学结构和细胞。方法包括体外和体内过程，其中体外方法包括化学反应。
• Pyrimidine Sulphonamide Derivatives as Chemokine Receptor Modulators
  申请人：Cheshire David Ranulf

  公开号：US20080096860A1

  公开（公告）日：2008-04-24

  A compound of formula (1), or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof and pharmaceutical compositions comprising these, all for use in the treatment of chemokine mediated diseases and disorders.

  公式（1）的化合物，或其药学上可接受的盐，溶剂或体内可水解的酯，以及包含这些化合物的制药组合物，均可用于治疗趋化因子介导的疾病和障碍。
• Polypeptides and Biosynthetic Pathways for the Production of Monatin and its Precursors
  申请人：Hicks Paula M.

  公开号：US20080274518A1

  公开（公告）日：2008-11-06

  Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.

  本文提供了从葡萄糖、色氨酸、吲哚-3-乳酸、吲哚-3-丙酮酸和2-羟基2-(吲哚-3-基甲基)-4-酮戊二酸中制备莫纳丁的方法和组合物。还揭示了制备吲哚-3-丙酮酸和2-羟基2-(吲哚-3-基甲基)-4-酮戊二酸中间体的方法。所提供的组合物包括核酸分子、多肽、化学结构和细胞。方法包括体外和体内过程，其中体外方法包括化学反应。
• POLYPEPTIDES AND BIOSYNTHETIC PATHWAYS FOR THE PRODUCTION OF MONATIN AND ITS PRECURSORS
  申请人：CARGILL, INCORPORATED

  公开号：US20130273616A1

  公开（公告）日：2013-10-17

  Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.

  提供了可以从葡萄糖、色氨酸、吲哚-3-乳酸、吲哚-3-丙酮酸和2-羟基2-(吲哚-3-基甲基)-4-酮戊酸制备莫纳丁的方法和组合物。还公开了制备吲哚-3-丙酮酸和2-羟基2-(吲哚-3-基甲基)-4-酮戊酸中间体的方法。提供的组成物包括核酸分子、多肽、化学结构和细胞。方法包括体外和体内过程，其中体外方法包括化学反应。