4-{2-[(Methylsulfonyl)amino]phenyl}-piperidine | 199105-05-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-{2-[(Methylsulfonyl)amino]phenyl}-piperidine
• 英文别名: Methanesulfonamide, N-[2-(4-piperidinyl)phenyl]-；N-(2-piperidin-4-ylphenyl)methanesulfonamide
• CAS: 199105-05-0
• 化学式: C₁₂H₁₈N₂O₂S
• 分子量: 254.353
• InChiKey: GSLUFLTYGIDPBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-{2-[(Methylsulfonyl)amino]phenyl}-piperidine 在 盐酸 、 sodium tetrahydroborate 、 双(2-氧代-3-恶唑烷基)次磷酰氯 、 magnesium sulfate 、 三乙胺 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 为溶剂， 生成 (S)-1-[2-benzylamino-3-(3,4-dichlorobenzyloxy)propionyl]-4-[2-(methanesulfonamido)phenyl]piperidine
  参考文献：
  名称：

  Serine derived NK1 antagonists 2: a pharmacophore model for arylsulfonamide binding

  摘要：

  Modifications to the spirocyclic aryl sulfonamide portion of serine derived NK, antagonists allow a partial pharmacophore model to be developed. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00319-9
• 作为产物：
  描述：

  4-(2-氨基苯基)-哌啶-1-羧酸叔丁酯 在 吡啶 、 盐酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 4-{2-[(Methylsulfonyl)amino]phenyl}-piperidine
  参考文献：
  名称：

  Serine derived NK1 antagonists 2: a pharmacophore model for arylsulfonamide binding

  摘要：

  Modifications to the spirocyclic aryl sulfonamide portion of serine derived NK, antagonists allow a partial pharmacophore model to be developed. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00319-9

文献信息

• Substituted piperidines and methods of use
  申请人：——

  公开号：US20040006067A1

  公开（公告）日：2004-01-08

  Selected substituted piperidine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的替代哌啶化合物对预防和治疗疾病，如肥胖等，具有有效性。该发明涵盖了新颖化合物、类似物、前药和其药用可接受盐，以及用于预防和治疗涉及黑素皮质素受体激活的疾病和其他疾病或病症的药物组合物和方法。该发明还涉及制备此类化合物的方法，以及在此类方法中有用的中间体。
• SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR
  申请人：Amgen, Inc.

  公开号：EP1416933B8

  公开（公告）日：2008-04-23
• US6977264B2
  申请人：——

  公开号：US6977264B2

  公开（公告）日：2005-12-20
• [EN] SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR<br/>[FR] PIPERIDINES SUBSTITUEES UTILISEES COMME MODULATEURS DU RECEPTEUR DE LA MELANOCORTINE
  申请人：AMGEM INC

  公开号：WO2003009847A1

  公开（公告）日：2003-02-06

  Selected substituted piperidine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
• Serine derived NK1 antagonists 2: a pharmacophore model for arylsulfonamide binding
  作者：J.M. Elliott、H. Broughton、M.A. Cascieri、G. Chicchi、I.T. Huscroft、M. Kurtz、A.M. MacLeod、S. Sadowski、G.I. Stevenson

  DOI：10.1016/s0960-894x(98)00319-9

  日期：1998.7

  Modifications to the spirocyclic aryl sulfonamide portion of serine derived NK, antagonists allow a partial pharmacophore model to be developed. (C) 1998 Elsevier Science Ltd. All rights reserved.