cis-5'-O-[4-(3,5-difluorophenyl)-2-oxo-1,2,3-dioxaphosphorin-2-yl]-2'-C-methyl-N4-(n-pentyloxycarbonyl)cytidine | 926655-38-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: cis-5'-O-[4-(3,5-difluorophenyl)-2-oxo-1,2,3-dioxaphosphorin-2-yl]-2'-C-methyl-N4-(n-pentyloxycarbonyl)cytidine
• 英文别名: pentyl N-[1-[(2R,3R,4R,5R)-5-[[4-(3,5-difluorophenyl)-2-oxo-1,3,2lambda5-dioxaphosphinan-2-yl]oxymethyl]-3,4-dihydroxy-3-methyloxolan-2-yl]-2-oxopyrimidin-4-yl]carbamate；pentyl N-[1-[(2R,3R,4R,5R)-5-[[4-(3,5-difluorophenyl)-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl]oxymethyl]-3,4-dihydroxy-3-methyloxolan-2-yl]-2-oxopyrimidin-4-yl]carbamate
• CAS: 926655-38-1
• 化学式: C₂₅H₃₂F₂N₃O₁₀P
• 分子量: 603.514
• InChiKey: OASTYOMSAKGNIG-YIMDTKBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  41
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  165
• 氢给体数：
  3
• 氢受体数：
  12

文献信息

• Novel 2'-c-methyl and 4'c-methyl nucleoside derivatives
  申请人：Erion Mark D.

  公开号：US20090118223A1

  公开（公告）日：2009-05-07

  Novel 2′-C-methyl nucleoside 5′-monophosphate and 4′-C-methyl nucleoside 5′-monophosphate derivatives, stereoisomers, and pharmaceutically acceptable salts or prodrugs thereof, their preparation, and their uses for the treatment of hepatitis C viral infection are described.