4-(4-{2-[adamantan-1-yl]ethyl}piperazin-1-yl)-N-({4-[(cyclohexylmethyl)amino]-3-nitrophenyl}sulfonyl)benzamide | 1335147-14-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(4-{2-[adamantan-1-yl]ethyl}piperazin-1-yl)-N-({4-[(cyclohexylmethyl)amino]-3-nitrophenyl}sulfonyl)benzamide
• 英文别名: 4-[4-[2-(1-adamantyl)ethyl]piperazin-1-yl]-N-[4-(cyclohexylmethylamino)-3-nitrophenyl]sulfonylbenzamide
• CAS: 1335147-14-2
• 化学式: C₃₆H₄₉N₅O₅S
• 分子量: 663.882
• InChiKey: SAAFHERPVPOMSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  47
• 可旋转键数：
  10
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  136
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
  申请人：Ding Hong

  公开号：US20110237553A1

  公开（公告）日：2011-09-29

  Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

  揭示了抑制抗凋亡Bcl-2蛋白活性的化合物，包含这些化合物的组合物以及治疗在其中表达抗凋亡Bcl-2蛋白的疾病的方法。
• Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
  申请人：Abbvie Inc.

  公开号：EP2757105A1

  公开（公告）日：2014-07-23

  This invention pertains to compounds, or therapeutically acceptable salts thereof, which inhibit the activity of Bcl-2 anti-apoptotic proteins, pharmaceutical compositions containing the compounds, and compounds and compositions for use in treating diseases during which anti-apoptotic Bcl-2 proteins are expressed.

  本发明涉及抑制 Bcl-2 抗凋亡蛋白活性的化合物或其治疗上可接受的盐类、含有这些化合物的药物组合物，以及用于治疗表达抗凋亡 Bcl-2 蛋白的疾病的化合物和组合物。
• METHOD FOR PRODUCING RUBBER COMPOSITION, AND RUBBER COMPOSITION
  申请人：Bridgestone Corporation

  公开号：EP2957587A1

  公开（公告）日：2015-12-23

  We provide a method for producing a rubber composition that includes a rubber component (A) including natural rubber, at least one filler (B) selected from an inorganic filler and carbon black, and a hydrazide compound (C), the method comprising compounding in an optional preliminary compounding stage and a plurality of compounding stages, and adding the hydrazide compound (C) and kneading in the preliminary compounding stage and/or a first compounding stage, the hydrazide compound (C) being represented by general formula (I): R-CONHNH2, where R represents an alkyl group having from 1 to 30 carbon atoms, a cycloalkyl group having from 3 to 30 carbon atoms, or an aryl group. We also provide a rubber composition produced with this method.

  我们提供了一种生产橡胶组合物的方法，该组合物包括包括天然橡胶在内的橡胶组分（A）、至少一种选自无机填料和炭黑的填料（B）以及酰肼化合物（C），该方法包括在任选的初步混炼阶段和多个混炼阶段中进行混炼，以及在初步混炼阶段和/或第一混炼阶段中加入酰肼化合物（C）并捏合，酰肼化合物（C）由通式（I）表示：R-CONHNH2，其中 R 代表具有 1 至 30 个碳原子的烷基、具有 3 至 30 个碳原子的环烷基或芳基。我们还提供了一种用这种方法生产的橡胶组合物。
• METHOD FOR MANUFACTURING RUBBER COMPOSITION, AND RUBBER COMPOSITION
  申请人：Bridgestone Corporation

  公开号：EP3196232A1

  公开（公告）日：2017-07-26

  Provided is a method for producing a rubber composition that includes a rubber component (A) including natural rubber, at least one filler (B) selected from an inorganic filler and carbon black, and a monohydrazide compound (C) supported on a solid. The monohydrazide compound (C) is represented by general formula (I): R-CONHNH2, where R represents an alkyl group having from 1 to 30 carbon atoms, a cycloalkyl group having from 3 to 30 carbon atoms, or an aryl group. The method comprises compounding in an optional preliminary compounding stage and a plurality of compounding stages, and adding the monohydrazide compound (C) supported on the solid and kneading in the preliminary compounding stage and/or a first compounding stage. Also provided is a rubber composition produced with this method.

  本发明提供了一种生产橡胶组合物的方法，该组合物包括天然橡胶在内的橡胶成分（A）、至少一种选自无机填料和炭黑的填料（B）以及支撑在固体上的单酰肼化合物（C）。单酰肼化合物 (C) 由通式 (I) 表示：R-CONHNH2，其中 R 代表具有 1 至 30 个碳原子的烷基、具有 3 至 30 个碳原子的环烷基或芳基。该方法包括在任选的初步混炼阶段和多个混炼阶段中进行混炼，并在初步混炼阶段和/或第一混炼阶段中加入支撑在固体上的单酰肼化合物（C）并进行捏合。此外，还提供了一种用该方法生产的橡胶组合物。
• Method for producing rubber composition, and rubber composition
  申请人：BRIDGESTONE CORPORATION

  公开号：US10087292B2

  公开（公告）日：2018-10-02

  Provided is a method for producing a rubber composition that includes a rubber component (A) including natural rubber, at least one filler (B) selected from an inorganic filler and carbon black, and a monohydrazide compound (C) supported on a solid. The monohydrazide compound (C) is represented by general formula (I): R—CONHNH2, where R represents an alkyl group having from 1 to 30 carbon atoms, a cycloalkyl group having from 3 to 30 carbon atoms, or an aryl group. The method comprises compounding in an optional preliminary compounding stage and a plurality of compounding stages, and adding the monohydrazide compound (C) supported on the solid and kneading in the preliminary compounding stage and/or a first compounding stage. Also provided is a rubber composition produced with this method.

  本发明提供了一种生产橡胶组合物的方法，该组合物包括天然橡胶在内的橡胶成分（A）、至少一种选自无机填料和炭黑的填料（B）以及支撑在固体上的单酰肼化合物（C）。单酰肼化合物 (C) 由通式 (I) 表示：R-CONHNH2，其中 R 代表具有 1 至 30 个碳原子的烷基、具有 3 至 30 个碳原子的环烷基或芳基。该方法包括在任选的初步混炼阶段和多个混炼阶段中进行混炼，并在初步混炼阶段和/或第一混炼阶段中加入支撑在固体上的单酰肼化合物（C）并进行捏合。此外，还提供了一种用该方法生产的橡胶组合物。