(S)-2-methyl-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-thiazol-2-yl}-amide) | 1163705-79-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (S)-2-methyl-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-thiazol-2-yl}-amide)
• 英文别名: (2S)-2-methyl-1-N-[4-methyl-5-[2-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
• CAS: 1163705-79-0
• 化学式: C₂₀H₂₈N₈O₂S
• 分子量: 444.561
• InChiKey: DNJBCMSIJXJONL-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  149
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Organic Compounds
  申请人：Caravatti Giorgio

  公开号：US20090163469A1

  公开（公告）日：2009-06-25

  The present invention relates to compounds of formula I and its salts, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.

  本发明涉及公式I的化合物及其盐，其中取代基如描述中所定义，以及该化合物在治疗通过抑制磷脂酰肌醇3-激酶改善的疾病中的应用。
• US8940771B2
  申请人：——

  公开号：US8940771B2

  公开（公告）日：2015-01-27
• [EN] THIAZOLE DERIVATIVES USED AS PI 3 KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE THIAZOLE UTILISÉS COMME INHIBITEUR DE LA PI 3 KINASE
  申请人：NOVARTIS AG

  公开号：WO2009080694A1

  公开（公告）日：2009-07-02

  The present invention relates to compounds of Formula (I): and its salts, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.