(2S,2'S,2''S,4S,4'S,4''S)-4,4',4''-(4,4',4''-(benzene-1,3,5-triyltris(oxy))tris(methylene)tris(1H-1,2,3-triazole-4,1-diyl))tris(pyrrolidine-4,2-diyl)tris(diphenylmethanol) | 1041199-46-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (2S,2'S,2''S,4S,4'S,4''S)-4,4',4''-(4,4',4''-(benzene-1,3,5-triyltris(oxy))tris(methylene)tris(1H-1,2,3-triazole-4,1-diyl))tris(pyrrolidine-4,2-diyl)tris(diphenylmethanol)
• CAS: 1041199-46-5
• 化学式: C₆₆H₆₆N₁₂O₆
• 分子量: 1123.33
• InChiKey: GOISDDLKPCSURE-FRAJVJQYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.72
• 重原子数：
  84.0
• 可旋转键数：
  21.0
• 环数：
  13.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  216.6
• 氢给体数：
  6.0
• 氢受体数：
  18.0

反应信息

• 作为产物：
  描述：

  ((2S,4S)-4-azidopyrrolidin-2-yl)diphenylmethanol 、 1,3,5-三(炔丙基氧代)苯 在 溴化三(三苯基磷)铜 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 72.0h， 以94%的产率得到(2S,2'S,2''S,4S,4'S,4''S)-4,4',4''-(4,4',4''-(benzene-1,3,5-triyltris(oxy))tris(methylene)tris(1H-1,2,3-triazole-4,1-diyl))tris(pyrrolidine-4,2-diyl)tris(diphenylmethanol)
  参考文献：
  名称：

  1,2,3-Triazole-linked dendrimers as a support for functionalized and recoverable catalysts for asymmetric borane reduction of prochiral ketones

  摘要：

  A series of new, functionalized, and chiral catalysts have been synthesized based on 1,2,3-triazole-linked dendrimers. It has been found that dendrimer 7f is an efficient catalyst for the enantio selective borane reduction of both electron-deficient and electron-rich ketones, and high enantioselectivities were obtained (up to 96%). The catalyst can be recovered and reused four times without a significant loss of catalytic activity. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.03.019