1-(5-chloro-thien-2-yl)piperazine | 337530-51-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(5-chloro-thien-2-yl)piperazine
• 英文别名: 1-(5-Chlorothiophen-2-yl)piperazine
• CAS: 337530-51-5
• 化学式: C₈H₁₁ClN₂S
• 分子量: 202.708
• InChiKey: WNWLFHMBSBWOPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SUBSTITUTED DIPEPTIDES HAVING NOS INHIBITING ACTIVITY
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1226159A1

  公开（公告）日：2002-07-31
• US6825200B1
  申请人：——

  公开号：US6825200B1

  公开（公告）日：2004-11-30
• [EN] SUBSTITUTED DIPEPTIDES HAVING NOS INHIBITING ACTIVITY<br/>[FR] DIPEPTIDES SUBSTITUES A ACTIVITE INHIBITRICE DES NOS
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2001032690A1

  公开（公告）日：2001-05-10

  The present invention relates to a compound of the formula (I) wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen, R2 is phenyl, pyridyl, thienyl or thiazolyl, each of which is optionally substituted by one or more substituents, or lower alkyl optionally substituted by one or more halogen atoms, R3 is hydrogen or lower alkoxy, R?4 and R5¿ are the same or different and each is hydrogen, lower alkyl or optionally protected hydroxy(lower)alkyl, and R6 is hydrogen or lower alkyl, or pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases in human being and animals.