| 1258388-04-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• CAS: 1258388-04-3
• 化学式: C₁₄H₁₀O₄
• 分子量: 242.231
• InChiKey: HCYRMKORHGLAJT-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 copper(l) iodide 、 三乙胺 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Synthetic and computational studies on liphagal: a natural product inhibitor of PI-3K

  摘要：

  The natural product liphagal has been shown to function as a reasonably potent and selective inhibitor of the key signaling enzyme PI-3K alpha. We have been interested in developing an analog class of PI-3K inhibitors based upon this unusual terpenoid natural product. Toward that end, we have evaluated the binding of the natural product to its target protein computationally and formulated a class of simplified analogs based on the structural analysis. Utilizing the cycloadduct derived from tetrabromocyclopropene and furan, we were able to generate a key, versatile scaffold upon which to pursue this analog design. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.058