US9359338, Exe. 055 | 1529765-96-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: US9359338, Exe. 055
• 英文别名: N-[4-[4-[[3-(4-ethylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]carbamoylamino]-2-fluorophenoxy]pyridin-2-yl]cyclopropanecarboxamide
• CAS: 1529765-96-5
• 化学式: C₂₉H₃₀F₄N₆O₃
• 分子量: 586.589
• InChiKey: FMDAPQFTHVIDJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  42
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  98.8
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• CYCLOPROPANECARBOXAMIDO-SUBSTITUTE AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS
  申请人：Crown Bioscience Inc. (Taiwan)

  公开号：US20150197511A1

  公开（公告）日：2015-07-16

  Provided are cyclopropanecarboxamido-substituted aromatic compounds that inhibit protein kinases and their use in anti-tumor area. In particular, tyrosine-kinase inhibitors and Raf-kinase inhibitors as anti-tumor agents, their preparation, pharmaceutical composition, and their use in the treatment of cancer are also provided.

  提供了一种环丙烷羧胺基取代芳香化合物，可抑制蛋白激酶，并在抗肿瘤领域中使用。具体来说，提供了酪氨酸激酶抑制剂和Raf激酶抑制剂作为抗肿瘤药物，以及它们的制备、药物组合物和在癌症治疗中的应用。
• CYCLOPROPANECARBOXAMIDO-SUBSTITUTED AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS
  申请人：CB Therapeutics Inc.

  公开号：EP2864289B1

  公开（公告）日：2018-04-11
• Cyclopropanecarboxamido-Substituted Aromatic Compounds as Anti-tumor Agents
  申请人：CB THERAPEUTICS INC.

  公开号：US20160280664A1

  公开（公告）日：2016-09-29

  The present disclosure relates to novel cyclopropanecarboxamido-substituted aromatic compounds that inhibit protein kinases and their use in anti-tumor area. In particular, the disclosure relates to novel tyrosine-kinase inhibitors and Raf-kinase inhibitors as anti-tumor agents, their preparation, pharmaceutical composition, and their use in the treatment of cancer.
• US9359338B2
  申请人：——

  公开号：US9359338B2

  公开（公告）日：2016-06-07
• US9840477B2
  申请人：——

  公开号：US9840477B2

  公开（公告）日：2017-12-12