2-(4-(cyclopropylsulfonyl)-2-oxopyridin-1(2H)-yl)-N-(5-((4-(2-(dimethylamino)-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)-3-(tetrahydro-2H-pyran-4-yl)propanamide | 1036208-04-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(4-(cyclopropylsulfonyl)-2-oxopyridin-1(2H)-yl)-N-(5-((4-(2-(dimethylamino)-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)-3-(tetrahydro-2H-pyran-4-yl)propanamide
• 英文别名: 2-(4-cyclopropylsulfonyl-2-oxopyridin-1-yl)-N-[5-[[4-[2-(dimethylamino)-2-oxoethyl]piperazin-1-yl]methyl]-1,3-thiazol-2-yl]-3-(oxan-4-yl)propanamide
• CAS: 1036208-04-4
• 化学式: C₂₈H₄₀N₆O₆S₂
• 分子量: 620.794
• InChiKey: ODGUTAAHJOBQFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  42
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  169
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• GLUCOKINASE ACTIVATORS
  申请人：Cheruvallath Zacharia

  公开号：US20090105255A1

  公开（公告）日：2009-04-23

  Compounds of the following formula are provided for use with glucokinase: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
• Glucokinase Activators
  申请人：Cheruvallath Zacharia

  公开号：US20120252814A1

  公开（公告）日：2012-10-04

  Compounds of the following formula are provided for use with glucokinase: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
• US8163779B2
  申请人：——

  公开号：US8163779B2

  公开（公告）日：2012-04-24
• US8530499B2
  申请人：——

  公开号：US8530499B2

  公开（公告）日：2013-09-10