(4S,5S)-4-isobutyl-5-(6-methyl-3-oxoheptyl)oxazolidin-2-one ethylene ketal | 109864-60-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4S,5S)-4-isobutyl-5-(6-methyl-3-oxoheptyl)oxazolidin-2-one ethylene ketal
• 英文别名: (4S,5S)-5-[2-[2-(3-methylbutyl)-1,3-dioxolan-2-yl]ethyl]-4-(2-methylpropyl)-1,3-oxazolidin-2-one
• CAS: 109864-60-0
• 化学式: C₁₇H₃₁NO₄
• 分子量: 313.437
• InChiKey: JNGARTRBCNGMJT-GJZGRUSLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.47
• 重原子数：
  22.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  56.79
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (4S,5S)-4-isobutyl-5-(6-methyl-3-oxoheptyl)oxazolidin-2-one ethylene ketal 在 barium dihydroxide 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 21.0h， 以73%的产率得到(4S,5S)-4-amino-2,11-dimethyl-5-hydroxy-8-oxododecane ethylene ketal
  参考文献：
  名称：

  Renin inhibitors. Dipeptide analogs of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond

  摘要：

  A series of dipeptide analogues of angiotensinogen have been prepared and evaluated for their ability to inhibit the aspartic proteinase renin. The compounds were derived from the renin substrate by replacing the scissile amide bond with a transition-state mimic and by incorporating bioisosteric replacements for the Val-10 amide bond. Analogue 21a exhibited an IC50 of 7.6 nM against purified human renin, showed high specificity for this enzyme, and produced a hypotensive response in anesthetized, salt-depleted cynomolgus monkeys.

  DOI：

  10.1021/jm00393a008
• 作为产物：
  描述：

  (4S,5S)-4-isobutyl-5-(2-formylethyl)oxazolidin-2-one 在 铬酸 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 丙酮 、 甲苯 为溶剂， 反应 10.0h， 生成 (4S,5S)-4-isobutyl-5-(6-methyl-3-oxoheptyl)oxazolidin-2-one ethylene ketal
  参考文献：
  名称：

  Renin inhibitors. Dipeptide analogs of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond

  摘要：

  A series of dipeptide analogues of angiotensinogen have been prepared and evaluated for their ability to inhibit the aspartic proteinase renin. The compounds were derived from the renin substrate by replacing the scissile amide bond with a transition-state mimic and by incorporating bioisosteric replacements for the Val-10 amide bond. Analogue 21a exhibited an IC50 of 7.6 nM against purified human renin, showed high specificity for this enzyme, and produced a hypotensive response in anesthetized, salt-depleted cynomolgus monkeys.

  DOI：

  10.1021/jm00393a008

文献信息

• BOLIS, GIORGIO;FUNG, ANTHONY K. L.;GREER, JONATHAN;KLEINERT, HOLLIS D.;MA+, J. MED. CHEM., 30,(1987) N 10, 1729-1737
  作者：BOLIS, GIORGIO、FUNG, ANTHONY K. L.、GREER, JONATHAN、KLEINERT, HOLLIS D.、MA+

  DOI：——

  日期：——