2-Chloro-1-[4-(3,5-dichloropyridin-2-yl)piperazin-1-yl]ethan-1-one | 1258641-27-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-Chloro-1-[4-(3,5-dichloropyridin-2-yl)piperazin-1-yl]ethan-1-one
• 英文别名: 2-chloro-1-[4-(3,5-dichloropyridin-2-yl)piperazin-1-yl]ethanone
• CAS: 1258641-27-8
• 化学式: C₁₁H₁₂Cl₃N₃O
• mdl: MFCD17976965
• 分子量: 308.6
• InChiKey: ASRKRHZMWQUUCX-UHFFFAOYSA-N

物化性质

• 沸点：
  473.9±45.0 °C(Predicted)
• 密度：
  1.452±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  36.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20190290778A1

  公开（公告）日：2019-09-26

  Provided herein, inter alia, are methods and compounds for targeted autophagy.

  本文提供了针对靶向自噬的方法和化合物。
• COVALENT TARGETING OF E3 LIGASES
  申请人：The Regents of the University of California

  公开号：US20210369731A1

  公开（公告）日：2021-12-02

  Disclosed herein, inter alia, are compositions and methods for targeting E3 ligases. In an aspect is a targeted protein degrader including 1) a targeted protein binder and 2) an E3 Ubiquitin ligase binder, wherein the E3 Ubiquitin ligase is human RNF4 or human RNF114. In an aspect is provided a pharmaceutical composition including a compound as described herein, including embodiments, and a pharmaceutically acceptable excipient.