1-[2-(2-Ethoxyethoxy)phenyl]piperazine | 350047-43-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-[2-(2-Ethoxyethoxy)phenyl]piperazine
• CAS: 350047-43-7
• 化学式: C₁₄H₂₂N₂O₂
• 分子量: 250.341
• InChiKey: OEXVCWCMBSRHEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  33.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Method for the preparation of substituted benzene derivatives
  申请人：H. Lundbeck A/S

  公开号：US20030040639A1

  公开（公告）日：2003-02-27

  A method for the preparation of selectively substituted benzene derivatives by application of solid phase synthesis is disclosed. In particular, the invention provides a novel method for the preparation of substituted benzene derivatives containing two or three groups bound to the benzene ring via nitrogen-, oxygen-, sulphur-, selenium- or carbon-carbon bonds, by application of solid phase chemistry alone or in combination with post cleavage solution phase derivatisation.

  本发明公开了一种通过应用固相合成的方法制备有选择性取代的苯衍生物。具体而言，本发明提供了一种新的方法，通过仅应用固相化学或与后解离溶液相衍生化合物相结合，制备含有通过氮、氧、硫、硒或碳-碳键与苯环结合的两个或三个基团的取代苯衍生物的方法。
• A METHOD FOR THE PREPARATION OF SUBSTITUTED BENZENE DERIVATIVES
  申请人：H. Lundbeck A/S

  公开号：EP1246819A1

  公开（公告）日：2002-10-09
• [EN] A METHOD FOR THE PREPARATION OF SUBSTITUTED BENZENE DERIVATIVES<br/>[FR] PROCEDE DE PREPARATION DE DERIVES DE BENZENE SUBSTITUE
  申请人：LUNDBECK & CO AS H

  公开号：WO2001049681A1

  公开（公告）日：2001-07-12

  A method for the preparation of selectively substituted benzene derivatives by application of solid phase synthesis is disclosed. In particular, the invention provides a novel method for the preparation of substituted benzene derivatives containing two or three groups bound to the benzene ring via nitrogen-, oxygen-, sulphur-, selenium- or carbon-carbon bonds, by application of solid phase chemistry alone or in combination with post cleavage solution phase derivatisation.