N2-(1-benzylpiperidin-4-yl)-N4-mesityl-6-methoxy-1,3,5-triazine-2,4-diamine | 1352803-97-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N2-(1-benzylpiperidin-4-yl)-N4-mesityl-6-methoxy-1,3,5-triazine-2,4-diamine
• 英文别名: N2-(1-benzyl-4-piperidyl)-6-methoxy-N4-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamine；2-N-(1-benzylpiperidin-4-yl)-6-methoxy-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamine
• CAS: 1352803-97-4
• 化学式: C₂₅H₃₂N₆O
• 分子量: 432.569
• InChiKey: SVLPKKKLGPYXHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  75.2
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N2-mesityl-6-methoxy-N4-(1-Boc-piperidin-4-yl)-1,3,5-triazine-2,4-diamine 在 potassium carbonate 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 N2-(1-benzylpiperidin-4-yl)-N4-mesityl-6-methoxy-1,3,5-triazine-2,4-diamine
  参考文献：
  名称：

  Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors

  摘要：

  A novel series of piperidine-substituted triazine derivatives have been synthesized and evaluated for anti-HIV activities in MT-4 cells. Most compounds displayed extremely promising activity against wildtype HIV-1 with EC50 values in low nanomolar concentration, better than that of Nevirapine, Delavirdine, Zidovudine and Dideoxycitidine, and higher potency towards the resistant mutant strain K103N/Y181C than that of Nevirapine and Delavirdine. Selected compounds were also assayed against reverse transcriptase with lower IC50 values than that of Nevirapine. The structure-activity relationship (SAR) of these novel structural congeners was also discussed. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.02.019

文献信息

• Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors
  作者：Xuwang Chen、Peng Zhan、Christophe Pannecouque、Jan Balzarini、Erik De Clercq、Xinyong Liu

  DOI：10.1016/j.ejmech.2012.02.019

  日期：2012.5

  A novel series of piperidine-substituted triazine derivatives have been synthesized and evaluated for anti-HIV activities in MT-4 cells. Most compounds displayed extremely promising activity against wildtype HIV-1 with EC50 values in low nanomolar concentration, better than that of Nevirapine, Delavirdine, Zidovudine and Dideoxycitidine, and higher potency towards the resistant mutant strain K103N/Y181C than that of Nevirapine and Delavirdine. Selected compounds were also assayed against reverse transcriptase with lower IC50 values than that of Nevirapine. The structure-activity relationship (SAR) of these novel structural congeners was also discussed. (C) 2012 Elsevier Masson SAS. All rights reserved.