2-chloro-N-(4-chloro-3-(2-(2-(dimethylamino)ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-6-(4-(4-methylpiperazin-1-yl)-benzylamino)-isonicotinamide | 1192310-15-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-chloro-N-(4-chloro-3-(2-(2-(dimethylamino)ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-6-(4-(4-methylpiperazin-1-yl)-benzylamino)-isonicotinamide
• 英文别名: 2-chloro-N-[4-chloro-3-[2-[2-(dimethylamino)ethylamino]-8-methoxy-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]-6-[[4-(4-methylpiperazin-1-yl)phenyl]methylamino]pyridine-4-carboxamide
• CAS: 1192310-15-8
• 化学式: C₃₆H₄₀Cl₂N₁₀O₃
• 分子量: 731.685
• InChiKey: ICCGNSYKLBSPRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  51
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  131
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• RAF INHIBITORS
  申请人：BACKES Alexander

  公开号：US20110257207A1

  公开（公告）日：2011-10-20

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

  本发明提供了吡啶并[2,3-d]嘧啶-7-酮的衍生物。这些化合物是Raf等激酶的抑制剂，包括表现出抗增殖活性的化合物，包括对肿瘤细胞的抗活性，并且在治疗癌症等疾病方面是有用的。
• Improved raf inhibitors
  申请人：Forma Therapeutics, Inc.

  公开号：EP2112150B1

  公开（公告）日：2013-10-16
• US8232283B2
  申请人：——

  公开号：US8232283B2

  公开（公告）日：2012-07-31
• [EN] IMPROVED RAF INHIBITORS<br/>[FR] INHIBITEURS DE RAF AMÉLIORÉS
  申请人：GPC BIOTECH AG

  公开号：WO2009130015A1

  公开（公告）日：2009-10-29

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.