CAA-R-PEG3-biotin | 1357582-33-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: CAA-R-PEG3-biotin
• CAS: 1357582-33-2
• 化学式: C₂₈H₅₁ClN₈O₇S
• 分子量: 679.281
• InChiKey: KUTBXULUWABTSR-UEOMBKFZSA-N

反应信息

• 作为产物：
  描述：

  在 三甲基-丙-2-基硅烷 、 水 、 三氟乙酸 作用下， 反应 3.0h， 生成 CAA-R-PEG3-biotin
  参考文献：
  名称：

  Novel inhibitors of surface layer processing in Clostridium difficile

  摘要：

  Clostridium difficile, a leading cause of hospital-acquired bacterial infection, is coated in a dense surface layer (S-layer) that is thought to provide both physicochemical protection and a scaffold for host-pathogen interactions. The key structural components of the S-layer are two proteins derived from a polypeptide precursor, SlpA, via proteolytic cleavage by the protease Cwp84. Here, we report the design, synthesis and in vivo characterization of a panel of protease inhibitors and activity-based probes (ABPs) designed to target Slayer processing in live C. difficile cells. Inhibitors based on substrate-mimetic peptides bearing a C-terminal Michael acceptor warhead were found to be promising candidates for further development. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.06.042