1-甲基-4-[1-(4-哌啶基)-4-哌啶基]哌嗪 | 1629218-99-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 1-甲基-4-[1-(4-哌啶基)-4-哌啶基]哌嗪
• 英文名称: 1-Methyl-4-[1-(4-piperidyl)-4-piperidyl]piperazine
• 英文别名: 1-methyl-4-(1-piperidin-4-ylpiperidin-4-yl)piperazine
• CAS: 1629218-99-0
• 化学式: C₁₅H₃₀N₄
• 分子量: 266.43
• InChiKey: VVNRVKMOTTTYKS-UHFFFAOYSA-N

物化性质

• 熔点：
  87.0 to 91.0 °C
• 沸点：
  375.1±10.0 °C(Predicted)
• 密度：
  1.041±0.06 g/cm3(Predicted)
• 溶解度：
  溶于甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.8
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险性防范说明：
  P264,P280,P302+P352,P305+P351+P338,P321,P332+P313,P337+P313,P362
• 危险性描述：
  H315,H319

文献信息

• Therapeutic Agent for Type 2 Diabetes
  申请人：NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY

  公开号：US20160060235A1

  公开（公告）日：2016-03-03

  An object of the present invention is to provide a novel therapeutic agent for a patient with type 2 diabetes, a cause of which is the abnormal synthesis of insulin attributed to the abnormal modification of tRNA Lys (UUU) in pancreatic β cells having Cdkal1 gene mutation. The present inventors have used (1) a screening system using E. coli in which correct translation into luciferase requires frameshift resulting from mistranslation during protein translation, (2) a screening system using the pancreatic islet of Langerhans isolated from a pancreatic β cell-specific Cdkal1-deficient mouse, and (3) a screening system using a pancreatic β cell-specific Cdkal1-deficient mouse, and found that a compound represented by any of the following formulas (I) to (III) can serve as a therapeutic agent for a patient with type 2 diabetes with Cdkal1 gene mutation resulting in the reduced ability to secrete insulin.

  本发明的一个目的是为2型糖尿病患者提供一种新型治疗剂，其原因是由于胰岛素的异常合成归因于胰岛β细胞中tRNALys(UUU)的异常修饰，其具有Cdkal1基因突变。本发明者已经使用了（1）使用大肠杆菌的筛选系统，其中正确的翻译成荧光酶需要在蛋白质翻译过程中由于错误翻译而导致的移码，（2）使用从胰岛β细胞特异性Cdkal1缺陷小鼠中分离的Langerhans胰岛的筛选系统，以及（3）使用胰岛β细胞特异性Cdkal1缺陷小鼠的筛选系统，并发现以下任一式（I）至（III）所代表的化合物可以作为一种治疗剂，用于具有Cdkal1基因突变且导致胰岛素分泌能力降低的2型糖尿病患者。
• Etchant, replenishment solution and method for forming copper wiring
  申请人：MEC COMPANY LTD.

  公开号：US10174428B2

  公开（公告）日：2019-01-08

  An etchant for copper includes an acid and one or more compounds selected from the group consisting of an aliphatic noncyclic compound, an aliphatic heterocyclic compound and a heteroaromatic compound. The aliphatic noncyclic compound is a saturated aliphatic noncyclic compound (A) including only two or more nitrogen atoms as heteroatoms, and 2 to 10 carbon atoms. The aliphatic heterocyclic compound is a compound (B) including a five-, six-, or seven-membered ring having one or more nitrogen atoms as one or more heteroatoms constituting the ring. The heteroaromatic compound is a compound (C) including a six-membered heteroaromatic ring having one or more nitrogen atoms as one or more heteroatoms constituting the ring.

  铜的蚀刻剂包括酸和一种或多种选自脂肪族非环化合物、脂肪族杂环化合物和杂芳香族化合物的化合物。脂肪族非环化合物是饱和脂肪族非环化合物 (A)，只包括两个或两个以上的氮原子作为杂原子，以及 2 至 10 个碳原子。脂族杂环化合物是一种化合物（B），包括一个五元环、六元环或七元环，其中有一个或多个氮原子作为构成环的一个或多个杂原子。杂芳香族化合物是一种化合物（C），包括一个六元杂芳香环，该环具有一个或多个氮原子作为构成环的一个或多个杂原子。
• Film forming composition and film forming method using the same
  申请人：Merck Patent GmbH

  公开号：US11161982B2

  公开（公告）日：2021-11-02

  [Problem] To provide a film forming composition and a film forming method capable of forming a film excellent in gas barrier properties. [Means for Solution] A film forming composition comprising a polysilazane, an organic solvent and an additive having a specific structure, and a film forming method comprising applying the composition on a substrate and exposing the composition to light. This specific additive is represented by a specific general formula among those having a nonconjugated cyclic structure composed of atoms selected from the group consisting of carbon, nitrogen and oxygen in the structure.

  [问题]提供一种成膜组合物和一种成膜方法，能够形成气体阻隔性能优异的薄膜。[解决方法]一种成膜组合物，由聚硅氧烷、有机溶剂和具有特定结构的添加剂组成；以及一种成膜方法，包括将该组合物涂在基底上并将该组合物曝光。该特定添加剂由具有非共轭环状结构的添加剂中的一个特定通式表示，该结构中的原子选自碳、氮和氧组成的组。
• ETCHANT, REPLENISHMENT SOLUTION AND METHOD FOR FORMING COPPER WIRING
  申请人：MEC COMPANY LTD.

  公开号：US20170260632A1

  公开（公告）日：2017-09-14

  An etchant for copper includes an acid and one or more compounds selected from the group consisting of an aliphatic noncyclic compound, an aliphatic heterocyclic compound and a heteroaromatic compound. The aliphatic noncyclic compound is a saturated aliphatic noncyclic compound (A) including only two or more nitrogen atoms as heteroatoms, and 2 to 10 carbon atoms. The aliphatic heterocyclic compound is a compound (B) including a five-, six-, or seven-membered ring having one or more nitrogen atoms as one or more heteroatoms constituting the ring. The heteroaromatic compound is a compound (C) including a six-membered heteroaromatic ring having one or more nitrogen atoms as one or more heteroatoms constituting the ring.
• FILM FORMING COMPOSITION AND FILM FORMING METHOD USING THE SAME
  申请人：Merck Patent GmbH

  公开号：US20210115253A1

  公开（公告）日：2021-04-22

  [Problem] To provide a film forming composition and a film forming method capable of forming a film excellent in gas barrier properties. [Means for Solution] A film forming composition comprising a polysilazane, an organic solvent and an additive having a specific structure, and a film forming method comprising applying the composition on a substrate and exposing the composition to light. This specific additive is represented by a specific general formula among those having a nonconjugated cyclic structure composed of atoms selected from the group consisting of carbon, nitrogen and oxygen in the structure.