N-(tert-butyl)-4-{1'-[3-(dimethylamino)-1,2,4-thiadiazol-5-yl]-4,4'-bipiperidin-1-yl}-2-fluorobenzamide | 1039743-85-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-(tert-butyl)-4-{1'-[3-(dimethylamino)-1,2,4-thiadiazol-5-yl]-4,4'-bipiperidin-1-yl}-2-fluorobenzamide
• 英文别名: N-tert-butyl-4-[4-[1-[3-(dimethylamino)-1,2,4-thiadiazol-5-yl]piperidin-4-yl]piperidin-1-yl]-2-fluorobenzamide
• CAS: 1039743-85-5
• 化学式: C₂₅H₃₇FN₆OS
• 分子量: 488.673
• InChiKey: ZZMVOWNWUNWRAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  92.8
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：Wood Harold B.

  公开号：US20100029688A1

  公开（公告）日：2010-02-04

  Bipiperidinyl compounds of the formula I, are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.

  公开了式I的双哌啶化合物，可用于治疗或预防2型糖尿病和类似疾病。药学上可接受的盐和溶剂也包括在内。这些化合物是G蛋白偶联受体GPR-119的激动剂。
• BIPIPERIDINYL COMPOUNDS, COMPOSITIONS, CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：WOOD HAROLD B.

  公开号：US20120178681A1

  公开（公告）日：2012-07-12

  Bipiperidinyl compounds of the formula I, are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.

  公开了式I的双哌啶化合物，可用于治疗或预防2型糖尿病和类似疾病。药学上可接受的盐和溶剂也包括在内。这些化合物可用作G蛋白偶联受体GPR-119的激动剂。
• US8445499B2
  申请人：——

  公开号：US8445499B2

  公开（公告）日：2013-05-21
• [EN] BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT<br/>[FR] COMPOSÉS DE BIPIPÉRIDINYLE, COMPOSITIONS CONTENANT CES COMPOSÉS ET PROCÉDÉS DE TRAITEMENT
  申请人：MERCK & CO INC

  公开号：WO2008085316A1

  公开（公告）日：2008-07-17

  [EN] Bipiperidinyl compounds of the formula I, are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.
  [FR] L'invention concerne des composés de bipipéridinyle de formule I qui sont utiles pour traiter ou prévenir les diabètes de type 2 et des états similaires. L'invention concerne également des sels et des solvats pharmaceutiquement acceptables. Les composés sont utiles en tant qu'agonistes du récepteur GPR 119 couplé à la protéine G.